PMID: 16614420Apr 15, 2006Paper

Neoplastic transformation of BALB/3T3 cells and cell cycle of HL-60 cells are inhibited by mango (Mangifera indica L.) juice and mango juice extracts

The Journal of Nutrition
Susan S PercivalJennifer Pettit-Moore

Abstract

The mango, Mangifera indica L., is a fruit with high levels of phytochemicals, suggesting that it might have chemopreventative properties. In this study, whole mango juice and juice extracts were screened for antioxidant and anticancer activity. Antioxidant activity of the mango juice and juice extracts was measured by 3 standard in vitro methods. The results of the 3 methods were in general agreement, although different radicals were measured in each. Anticancer activity was measured by examining the effect on cell cycle kinetics and the ability to inhibit chemically induced neoplastic transformation of mammalian cell lines. Incubation of HL-60 cells with whole mango juice and mango juice fractions resulted in an inhibition of the cell cycle in the G(0)/G(1) phase. A fraction of the eluted mango juice with low peroxyl radical scavenging ability was most effective in arresting cells in the G(0)/G(1) phase. Whole mango juice was effective in reducing the number of transformed foci in the neoplastic transformation assay in a dose-dependent manner. These techniques provide valuable screening tools for health benefits derived from mango phytochemicals.

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Citations

Mar 6, 2013·Photodermatology, Photoimmunology & Photomedicine·Jae Hyoung SongSungwook Chae
Aug 29, 2014·Journal of Dietary Supplements·Sanjay S Karn, A V R L Narasimhacharya
Jul 23, 2015·Current Eye Research·Soo-Jin KimSang-Woo Park
May 27, 2009·International Journal of Food Sciences and Nutrition·Pablo García-SolísMauricio Díaz-Muñoz
Jul 8, 2011·The British Journal of Nutrition·Edralin A LucasBrenda J Smith
Mar 7, 2007·Molecular Nutrition & Food Research·Sahdeo PrasadYogeshwer Shukla
Aug 31, 2019·Food Science and Technology International = Ciencia Y Tecnología De Los Alimentos Internacional·Chandra Bhushan T Pal, Girirajsinh C Jadeja
Jun 9, 2020·Critical Reviews in Food Science and Nutrition·Bilal MirzaAnupam Bishayee
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Dec 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiayi FanAmandeep K Sandhu
Mar 9, 2010·Journal of Agricultural and Food Chemistry·Giuliana D NorattoSusanne U Mertens-Talcott
Oct 9, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C M Ajila, U J S Prasada Rao

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