Neoplastic transformation of cultured mammalian cells by estrogens and estrogenlike chemicals

Environmental Health Perspectives
T Tsutsui, J C Barrett

Abstract

Estrogens are clearly carcinogenic in humans and rodents but the mechanisms by which these hormones induce cancer are only partially understood. Stimulation of cell proliferation and gene expression by binding to the estrogen receptor is one important mechanism in hormonal carcinogenesis; however, estrogenicity is not sufficient to explain the carcinogenic activity of all estrogens because some estrogens are not carcinogenic. Estrogens are nonmutagenic in many assays but exhibit specific types of genotoxic activity under certain conditions. We have studied extensively the mechanisms by which estrogens induce neoplastic transformation in a model in vitro system and our findings are summarized in this review. 17beta-Estradiol (E2) and diethylstilbestrol (DES) and their metabolites induce morphological and neoplastic transformation of Syrian hamster embryo (SHE) cells that express no measurable levels of estrogen receptor. Treatment of the cells with E2 or DES fails to induce DNA damage, chromosome aberrations and gene mutations in SHE cells but results in numerical chromosome aberrations (aneuploidy) that could arise from microtubule disruption or disfunction of mitotic apparatus. Estrogen-induced genotoxicity is detected in cell...Continue Reading

References

Jul 25, 1977·Biochemical and Biophysical Research Communications·J Goodman, P Hochstein
Dec 14, 1978·Biochemical and Biophysical Research Communications·M Metzler, J A McLachlan
Jan 1, 1992·Chemical & Pharmaceutical Bulletin·Y SatoK Ichinoseki
May 1, 1990·Mutation Research·J G Liehr
Jan 1, 1990·Free Radical Biology & Medicine·J G Liehr, D Roy
Dec 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S K Abraham
Mar 1, 1989·Breast Cancer Research and Treatment·N T TelangM P Osborne
Oct 1, 1989·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·S Peel, I Stewart
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G E Swaneck, J Fishman
Jan 1, 1988·Journal of Steroid Biochemistry·A E Wakeling, J Bowler
Dec 1, 1987·Environmental Health Perspectives·J C Barrett, R W Wiseman
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J G LiehrK Randerath
Jan 1, 1987·Cell Motility and the Cytoskeleton·W J WheelerB R Brinkley
Nov 1, 1986·British Journal of Cancer·L A BrintonJ F Fraumeni
Jan 1, 1985·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·K S Korach, J A McLachlan
Feb 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A W Hsie, T T Puck
Apr 15, 1971·The New England Journal of Medicine·A L HerbstD C Poskanzer
Jun 1, 1966·Biochemistry·J FishmanJ Cassouto
Jan 1, 1983·Annual Review of Physiology·J Fishman

❮ Previous
Next ❯

Citations

Nov 6, 2013·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Serkan YilmazSibel Erkal İlhan
Aug 29, 1998·Environmental Health Perspectives·D L DavisA J Sasco
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ayelet M SamuniJames B Mitchell
Jun 27, 2003·Environmental Health Perspectives·Julia Green Brody, Ruthann A Rudel
Oct 6, 2005·Reproductive Biology and Endocrinology : RB&E·Mohamed F M MitwallyMichael P Diamond
Aug 2, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J L SpearowM Barkley
Mar 24, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Volkan Baltaci, Hulusi B Zeyneloglu
Jul 19, 2011·Expert Review of Endocrinology & Metabolism·Jason L NellesGail S Prins
Oct 30, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·Dimitrios KloukosGeorge Eliades
Dec 23, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H MaeshimaT Yamada
Sep 16, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Akiko TakahashiHidehiko Sano
Apr 22, 2003·International Journal of Cancer. Journal International Du Cancer·Takeki TsutsuiJ Carl Barrett
Jul 1, 2006·Environmental Toxicology and Pharmacology·Maëlle CargouëtDaniel Perdiz
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·Y HirakuS Kawanishi
Mar 30, 2000·International Journal of Cancer. Journal International Du Cancer·T TsutsuiJ C Barrett
Jun 22, 2000·Environmental and Molecular Mutagenesis·A N JhaS J Hill
Jun 8, 2001·International Journal of Cancer. Journal International Du Cancer·H KanaiT Tsutsui
Sep 22, 2001·Biology of Reproduction·B T AkingbemiM P Hardy
Dec 3, 2016·Frontiers in Cell and Developmental Biology·Rainer G Hanselmann, Cornelius Welter
Feb 13, 2001·Regulatory Toxicology and Pharmacology : RTP·J G Liehr
Mar 5, 1999·Mutation Research·D Roy, J G Liehr

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.