Neospora caninum Recruits Host Cell Structures to Its Parasitophorous Vacuole and Salvages Lipids from Organelles

Eukaryotic Cell
Sabrina J NolanIsabelle Coppens

Abstract

Toxoplasma gondii and Neospora caninum, which cause the diseases toxoplasmosis and neosporosis, respectively, are two closely related apicomplexan parasites. They have similar heteroxenous life cycles and conserved genomes and share many metabolic features. Despite these similarities, T. gondii and N. caninum differ in their transmission strategies and zoonotic potential. Comparative analyses of the two parasites are important to identify the unique biological features that underlie the basis of host preference and pathogenicity. T. gondii and N. caninum are obligate intravacuolar parasites; in contrast to T. gondii, events that occur during N. caninum infection remain largely uncharacterized. We examined the capability of N. caninum (Liverpool isolate) to interact with host organelles and scavenge nutrients in comparison to that of T. gondii (RH strain). N. caninum reorganizes the host microtubular cytoskeleton and attracts endoplasmic reticulum (ER), mitochondria, lysosomes, multivesicular bodies, and Golgi vesicles to its vacuole though with some notable differences from T. gondii. For example, the host ER gathers around the N. caninum parasitophorous vacuole (PV) but does not physically associate with the vacuolar membrane;...Continue Reading

References

Aug 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B J Luft, J S Remington
Jun 1, 1991·Parasitology·F FoussardJ F Dubremetz
Feb 1, 1990·Nature·J L Goldstein, M S Brown
Nov 1, 1987·The Journal of protozoology·I CoppensP Baudhuin
Dec 1, 1993·Antimicrobial Agents and Chemotherapy·J BlaisS Chamberland
Jan 1, 1994·Methods in Cell Biology·D S RoosA L Moulton
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·T HackstadtD D Rockey
Nov 20, 1993·The Veterinary Record·J BarberB Tennant
Feb 1, 1996·Cell Structure and Function·E J de Melo, W de Souza
Feb 1, 1997·Comparative Immunology, Microbiology and Infectious Diseases·I Esteban-Redondo, E A Innes
Apr 29, 1998·International Journal for Parasitology·A HemphillM Jenkins
Oct 29, 1998·British Journal of Haematology·H P de LeeuwJ Voorberg
Jul 15, 1999·The Veterinary Record·D A GrahamJ Marks
Aug 6, 2000·International Journal for Parasitology·A Hemphill, B Gottstein
Dec 13, 2000·International Journal for Parasitology·A M TenterL M Weiss
Feb 7, 2001·The Journal of Cell Biology·H FölschI Mellman
Jun 14, 2002·International Journal for Parasitology·Nahid AzzouzRalph T Schwarz
Jun 22, 2002·International Journal for Parasitology·J P DubeyD S Lindsay
Sep 16, 2003·Molecular Biology of the Cell·Isabelle Coppens, Keith A Joiner
Mar 9, 2004·International Journal for Parasitology·Calvin JungMichael E Grigg
Mar 9, 2004·International Journal for Parasitology·A P SinaiR E Molestina
Mar 9, 2004·Molecular Biology of the Cell·Jagath R JunutulaRichard H Scheller
Apr 2, 2004·The Journal of Biological Chemistry·Verena KarstenKeith A Joiner
Apr 28, 2004·International Journal for Parasitology·Meredith Teilhet MorrisVern B Carruthers
Jun 11, 2004·Biophysical Journal·Sylvain V CostesStephen Lockett
Oct 27, 2004·Molecular and Biochemical Parasitology·Friederike QuittnatIsabelle Coppens
Mar 9, 2005·Molecular Microbiology·Vern B Carruthers, Michael J Blackman
Apr 28, 2005·Antimicrobial Agents and Chemotherapy·Sabrina SondaJean Pieters
May 13, 2005·Cellular Microbiology·Yoshifumi NishikawaIsabelle Coppens
Jun 1, 2005·Trends in Parasitology·Timothy J Dowse, Dominique Soldati
Sep 12, 2006·FEBS Letters·Tassula Proikas-CezanneAlfred Nordheim

❮ Previous
Next ❯

Citations

Jan 31, 2016·Biochimica Et Biophysica Acta·Maud Dumoux, Richard D Hayward
Oct 17, 2015·PLoS Pathogens·Pierre-Mehdi HammoudiDominique Soldati-Favre
Jun 3, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carlos M De Leon-RodriguezArturo Casadevall
Mar 23, 2017·Frontiers in Microbiology·Lei MaQun Liu
Mar 25, 2017·Acta Biochimica Et Biophysica Sinica·Jingquan DongXichen Zhang
Nov 10, 2017·Cellular Microbiology·Gaelle LentiniBarbara A Burleigh
May 6, 2020·Scientific Reports·Luiz Miguel PereiraAna Patrícia Yatsuda
Oct 8, 2020·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Anaiá da Paixão SeváFernando Ferreira
Feb 9, 2021·Frontiers in Veterinary Science·Iván Pastor-FernándezPilar Horcajo
Aug 20, 2021·Current Opinion in Microbiology·Tânia C MedeirosLena Pernas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.