Neostigmine antagonism of rocuronium block during anesthesia with sevoflurane, isoflurane or propofol

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
J E ReidA H Hayes

Abstract

To examine the influence of continuing administration of sevoflurane or isoflurane during reversal of rocuronium induced neuromuscular block with neostigmine. One hundred and twenty patients, divided into three equal groups, were randomly allocated to maintenance of anesthesia with sevoflurane, isoflurane or propofol. Neuromuscular block was induced with rocuronium and monitored using train-of-four (TOF) stimulation of the ulnar nerve and recording the force of contraction of the adductor pollicis muscle. Neostigmine was administered when the first response in TOF had recovered to 25%. At this time the volatile agent administration was stopped or propofol dosage reduced in half the patients in each group (n = 20 in each group). The times to attain TOF ratio of 0.8, and the number of patients attaining this end point within 15 min were recorded. The times (mean +/- SD) to recovery of the TOF ratio to 0.8 were 12.0 +/- 5.5 and 6.8 +/- 2.3 min in the sevoflurane continued and sevoflurane stopped groups, 9.0 +/- 8.3 and 5.5 +/- 3.0 min in the isoflurane continued and isoflurane stopped groups, and 5.2 +/- 2.8 and 4.7 +/- 1.5 min in the propofol continued and propofol stopped groups (P < 0.5-01). Only 9 and 15 patients in the sevofl...Continue Reading

References

Mar 1, 1990·British Journal of Anaesthesia·S S GillF Donati
Apr 1, 1982·British Journal of Anaesthesia·S Delisle, D R Bevan
Jan 1, 1996·Acta Anaesthesiologica Scandinavica·J Viby-MogensenD Ostergaard
Mar 7, 2000·Anesthesia and Analgesia·T J ZhouT Webb

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Citations

Jun 18, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Mohammad El-Orbany
Feb 19, 2009·Anaesthesia·R K Mirakhur
Aug 19, 2015·Journal of Clinical Monitoring and Computing·Fatma Gulcin Ozturk ArikanDondu Nisa Onder
Jul 26, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·M Beaussier, M A Boughaba
Aug 15, 2017·The Cochrane Database of Systematic Reviews·Ana-Marija HristovskaArash Afshari
Apr 30, 2009·European Journal of Anaesthesiology·Philippe E Dubois
Oct 6, 2005·Journal of Oral Rehabilitation·A MichelottiM Farella
Jun 13, 2013·Anesthesia and Analgesia·Yoshifumi KotakeJunzo Takeda
Feb 7, 2013·Current Opinion in Anaesthesiology·Andreas GüldnerMarcelo Gama de Abreu
May 16, 2009·Drugs·Lily P H Yang, Susan J Keam
Jun 16, 2018·Current Anesthesiology Reports·Guy Cammu
Jun 11, 2015·Veterinary Anaesthesia and Analgesia·Ronald S JonesMartina Mosing
Sep 28, 2010·Journal of Clinical Anesthesia·Wolfgang LedererKarin S Khuenl-Brady

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