Neovaginal malignant melanoma following surgery and radiation for vulvar squamous cell carcinoma

Gynecologic Oncology
P N LaraB Leigh

Abstract

The causal link between therapeutic irradiation and malignant melanoma has not been firmly established. The authors report a novel case of a malignant melanoma arising from a therapeutically irradiated neovagina reconstructed from skin flaps following radical vulvectomy with inguinal lymph node dissection 16 years earlier. The diagnosis was established by light microscopy and immunohistochemical staining. Reports of melanoma arising from sites of previous radiation therapy are reviewed. Our observations suggest that therapeutic radiation may be a factor in the development of malignant melanoma, particularly in non-sun-exposed areas, including the genital tract.

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Citations

Sep 30, 2000·Clinical and Experimental Dermatology·S J BeswickA G Smith
Oct 25, 2008·Journal of Pediatric Urology·Justine M Schober
Mar 26, 2005·Gynecologic Oncology·Arjan P Schouten van der VeldenTheo Wobbes
Jun 26, 2015·Journal of Lower Genital Tract Disease·Debra S Heller
Oct 24, 2002·Melanoma Research·I MendilciogluB Trak
Aug 26, 2017·Sexual Health·Vincent J CornelisseSonia R Grover

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