Neovascularization in experimental retinal venous obstruction in rabbits

Japanese Journal of Ophthalmology
M Tamura

Abstract

To investigate the later pathohistological changes in experimental retinal venous obstruction in rabbits. Experimental retinal venous obstruction was produced in retinal blood vessels of rabbits by trans-adventitial dropping of thrombin. Fundus observation was performed 3 months and 1 year thereafter. Retinal histological examinations were performed by fluorescein microscopy, light microscopy, and transmission electron microscopy. Vessels with a rete mirabile and arteriovenous anastomosis were observed after 3 months. On a flat gelatin-fluorescein preparation, regions with no perfusion, thought to be areas of vascular occlusion in the periphery, were observed extensively. Clear leakage of gelatin-added fluorescein was noted from vessels in the periphery, and minute neovascularization with a rete mirabile from these vessels was confirmed. Newly formed retinal vessels were also observed by transmission electron microscopy. The endothelial cells of these newly formed vessels had a large nucleus, a number of ribosomes, and thin basement membrane. Proliferative changes included glial cells that had penetrated into the basement membrane of ghost vessels. Our long-term observations confirmed that proliferative changes and neovasculari...Continue Reading

Citations

Jul 22, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hossein AmeriMark S Humayun
Mar 20, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Luís A AranaMark S Humayun
Apr 29, 2008·The Tohoku Journal of Experimental Medicine·Kaori SuzukiMitsuru Nakazawa
Feb 7, 2004·European Journal of Clinical Investigation·Y-C ChungA C-H Pan

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