PMID: 11931081Apr 5, 2002Paper

Neovascularization in the anterior segment of the rabbit eye by experimental anterior ischemia

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Akihiko TawaraYoshitaka Ohnishi

Abstract

To investigate the effects of anterior ischemia accompanied by neither retinal nor choroidal ischemia on the anterior segment of the eye. Both long posterior ciliary arteries in the right eye of 14 rabbits were directly cauterized with an electric coagulator. The eyes were enucleated 1, 2, 4, 7, 9 or 14 days after cauterization, then fixed with 4% paraformaldehyde. Semi-thin sections were studied by light microscopy. Several sections were stained with Griffonia simplicifolia lectin, which bound specifically to mammalian vascular endothelium. Other specimens were examined immunohistochemically for vascular endothelial growth factor (VEGF) protein. The tissue specimens of the first postoperative day were studied for expression of VEGF mRNA by in situ hybridization. Atrophy of the iris and ciliary body was seen after the second postoperative day. Corneal neovascularization appeared after 7 days. Neovascularization on the anterior surface of the iris and in the trabecular meshwork was detected after the ninth postoperative day. The proliferative tissues with newly formed vessels obstructed the iridocorneal angle 14 days after the treatment. There was no histological change in either the retina or choroid. Immunohistochemically, VEG...Continue Reading

Citations

Nov 18, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Efstathios T DetorakisVassilios P Kozobolis
Mar 5, 2005·Ophthalmology·Efstathios T DetorakisBradley R Straatsma
Sep 3, 2013·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Abbas BagheriDavid Silbert
Jan 18, 2006·Clinical Biochemistry·Jian-Ping Tong, Yu-Feng Yao
Sep 16, 2003·Retina·John R HeckenlivelyBo Chang
Oct 15, 2011·Ophthalmic Research·Xiao-Xu ZhouJian-Guo Wu

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