Neovascularization of surface demineralized dentin.

Journal of Periodontology
K S TwedenV P Terranova

Abstract

Uneventful healing of the wound site created by periodontal reconstructive surgery is crucial for the long term survival of the dentition. Wound healing has been shown to be initiated and mediated by matrix components and polypeptide growth factors. Neovascularization (or angiogenesis) is one of the most important events in the healing process of a wound site. Any increase in the degree and/or rate of neovascularization could result in more rapid or complete healing. Previously, we have shown that basic fibroblast growth factor (bFGF) selectively enhances periodontal ligament cell migration and proliferation. In addition, we have shown that FGF stimulates human umbilical vein endothelial cell migration and proliferation. In this study we examined whether human umbilical vein endothelial cells could be influenced to form capillary-like structures in a type I collagen stroma and on dentin surfaces in response to fibroblast growth factor (FGF). We observed tubule-like structures formed from a monolayer of endothelial cells within a type I collagen sponge in response to a gradient of FGF. Furthermore, we observed tubule-like structures formed from self-association of individual endothelial cells on partially demineralized dentin su...Continue Reading

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Citations

Mar 1, 1992·Journal of Periodontology·U M WikesjöK A Selvig
Mar 29, 2003·Archives of Oral Biology·K A Derringer, R W A Linden
Jun 29, 2000·Journal of Periodontology·S D HokettT E Van Dyke
Oct 1, 1996·Journal of Dental Research·K A DerringerR W Linden
Mar 6, 2003·Microscopy Research and Technique·Masaki ShimonoTakashi Inoue
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