Feb 5, 1976

Neovitamin B12 (cyano-13-epicobalamin)

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
R Bonnett

Abstract

Beta-Epimerization in the corrinoid system has recently emerged as a complicating factor in the latter stages of the total synthesis of vitamin B12 (Eschenmoser 1971; Woodward 1973). It has also found some application in biosynthetic studies on the origin of the methyl groups in ring C (Scott, Townsend & Cushley 1973; Scott, this Discussion p. 303). This paper sets out to review briefly the beta-epimerization of corrinoid polyamides, with particular reference to our work on the neo-series which provided the first established example of this phenomenon.

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Mentioned in this Paper

Study
Molecular Stereochemistry
Vitamin B 12
Methylate
Vitamin B12 [EPC]
Epimerization
Vitamin B12 Measurement
5-cyano-2'-deoxyuridine
Nylons
Anabolism

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