Nepalensinols D-G, new resveratrol oligomers from Kobresia nepalensis (Cyperaceae) as potent inhibitors of DNA topoisomerase II

Chemical & Pharmaceutical Bulletin
Masashi YamadaHiroshi Nozaki

Abstract

Four new resveratrol oligomers, nepalensinols D-G, were isolated from the stem of Kobresia nepalensis (Cyperaceae). The structures were determined by detailed NMR spectral analysis. The compounds were assessed for their inhibitory activity against human topoisomerase II, a potential target of anti-tumor agents. These stilbenoids showed potent inhibitory activity against human topoisomerase II with IC50 values of 5-15 microM.

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Citations

Feb 2, 2012·Natural Product Research·Adriano Antonio SilvaCelso Vataru Nakamura
Oct 12, 2010·Chemical & Pharmaceutical Bulletin·Tetsuro ItoMunekazu Iinuma
May 13, 2009·Antioxidants & Redox Signaling·Shazib Pervaiz, Andrea Lisa Holme
Jul 5, 2006·Biological & Pharmaceutical Bulletin·Masashi YamadaHiroshi Nozaki
Dec 23, 2015·Journal of Asian Natural Products Research·Xian-Fen Wang, Chun-Suo Yao
Nov 19, 2011·International Journal of Cancer. Journal International Du Cancer·Stefano LeoneRenata Cozzi
Jul 19, 2014·Journal of Asian Natural Products Research·Norizan AhmatJalifah Latip
Sep 10, 2016·BMC Complementary and Alternative Medicine·Napsiah Abd RahmanSharida Fakurazi
Sep 28, 2012·Natural Product Reports·Céline RivièreJean-Michel Mérillon
Jun 26, 2009·Natural Product Reports·Tao ShenHong-Xiang Lou
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Csilla Zsuzsanna DávidAndrea Vasas
Apr 4, 2015·Chemical Reviews·Mitchell H KeylorCorey R J Stephenson

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