Nephrectomy improves the survival of patients with locally advanced renal cell carcinoma

BJU International
Laurent ZiniPierre I Karakiewicz

Abstract

To examine the cancer-specific survival of patients treated with nephrectomy and compared it to that of patients managed without surgery. Of 43,143 patients with renal cell carcinoma (RCC) identified in the 1988-2004 Surveillance, Epidemiology and End Results database, 7068 had locally advanced RCC and with no distant metastasis. These patients had a nephrectomy (6786, 96.0%) or no surgical therapy (282, 4.0%). Multivariable Cox regression models, and matched and unmatched Kaplan-Meier survival analyses, were used to compare the effect of nephrectomy vs non-surgical therapy on cancer-specific survival. Also, competing-risks regression models adjusted for the effect of other-cause mortality. Covariates and matching variables consisted of age, gender, tumour size and year of diagnosis. The 1-, 2-, 5- and 10-year cancer-specific survival of patients who had nephrectomy was 88.9%, 88.1%, 68.6% and 57.5%, vs 44.8%, 30.6%, 14.5% and 10.6% for non-surgical therapy. In multivariable analyses, relative to nephrectomy, non-surgical therapy was associated with a 5.8-fold higher rate of cancer-specific mortality (P < 0.001). Non-surgical therapy was also associated with a 5.1-fold higher rate of cancer-specific mortality in matched analyse...Continue Reading

References

Apr 18, 2003·BJU International·A D BairdK F Parsons
Dec 6, 2003·The Oncologist·Lynn A Gloeckler RiesBrenda K Edwards
Jan 13, 2006·Journal of the National Comprehensive Cancer Network : JNCCN·William T McGivney
Feb 17, 2006·European Urology·Jean-Jacques PatardPatricia Fergelot
Aug 4, 2006·Cancer Control : Journal of the Moffitt Cancer Center·Alejandro Rodriguez, Wade J Sexton
Jan 27, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher G Wood
Feb 14, 2007·The Journal of Urology·A Karim KaderChristopher G Wood
Apr 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierre I KarakiewiczJean-Jacques Patard
Jun 19, 2007·The Journal of Urology·Inderbir S GillAndrew C Novick
Aug 19, 2007·The Journal of Urology·Tobias KlatteArie S Belldegrun
Aug 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jochen WalzPierre I Karakiewicz
Sep 18, 2007·The Journal of Urology·Vitaly MargulisChristopher G Wood

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Citations

Dec 7, 2010·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·J-J PatardUNKNOWN Oncology Committee of the French Association of Urology (CCAFU)
Dec 5, 2008·European Urology·Vincent CloutierPierre I Karakiewicz
Dec 24, 2014·La Presse médicale·Mehdi AfritHamouda Boussen
Jun 29, 2011·Expert Review of Anticancer Therapy·Frederik C RoosJoachim W Thüroff
Jul 3, 2009·Current Opinion in Urology·Frederik C RoosJoachim W Thüroff
Oct 16, 2019·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·K BensalahA Méjean

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