Nephrin - a biomarker of early glomerular injury

Biomarker Research
Yogavijayan KandasamyDonna Rudd

Abstract

Nephrin is a 180 KD trans-membrane protein expressed in glomerular podocytes. It was first identified in children with congenital nephrotic syndrome of the Finnish type (NPHS1). Nephrin forms an integral part of podocytes, which-together with endothelial cells and the basement-form the glomerular filtration barrier. Podocytopathies result in the detection of nephrin in the urine. We reviewed the literature to determine if urine nephrin measurements could become useful as a biomarker to detect early podocyte injury. Our search identified a total of 19 studies that have been published to date. The most common clinical conditions for which urine nephrin analyses were carried out included diabetic nephropathy, glomerulonephritis and pre-eclampsia. Nephrin measurement was carried out using commercially available ELISA kits, the messenger ribonucleic acid real-time polymerase chain Reaction, or electrophoresis. Nephrinuria showed positive correlation with proteinuria and severity of podocyte injury. In two studies, the level of nephrinuria declined in conjunction with clinical improvement in the patient following immunosuppressive treatment. Currently, there is no published data on the value of measuring urinary nephrin in pediatric ...Continue Reading

References

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Citations

Sep 13, 2015·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Yogavijayan KandasamyDonna Rudd
Nov 8, 2015·Journal of Proteomics·Gleb ZilbersteinPier Giorgio Righetti
Jul 15, 2016·Journal of Diabetes Research·Cristina GluhovschiBogdan Timar
Jun 18, 2016·International Urology and Nephrology·Ciorba Pop MarianaKacso Ina Maria
May 17, 2017·Pflügers Archiv : European journal of physiology·Janina Müller-Deile, Mario Schiffer
Mar 4, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yogavijayan KandasamyIan Mr Wright
Jul 20, 2018·Journal of Cellular and Molecular Medicine·Jiping SunAiping Yin
Sep 29, 2017·Critical Reviews in Clinical Laboratory Sciences·Nektaria Papadopoulou-MarketouIoannis Papassotiriou
Jun 16, 2017·Canadian Journal of Kidney Health and Disease·Carole G CampionSri N Batchu
Jun 19, 2020·Journal of Medical Biochemistry·Irena KostovskaDanica Labudovic
Sep 12, 2015·American Journal of Physiology. Renal Physiology·Jennifer C Sullivan, John D Imig
Sep 27, 2018·Frontiers in Medicine·Samuel Mon-Wei YuBelinda Jim
Apr 2, 2020·Journal of the Endocrine Society·Igor Kravets, Sandeep K Mallipattu
Nov 20, 2016·The Journal of Obstetrics and Gynaecology Research·Itsuko FurutaHisanori Minakami
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Aug 12, 2020·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Irena KostovskaDanica Labudovic
Jul 17, 2021·Indian Journal of Nephrology·Kishore KondapiSanthi Silambanan

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Methods Mentioned

BETA
ELISA
Electrophoresis
urine collections
biopsies
biopsy

Software Mentioned

Podocytes

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