Nephrin and podocin loss is prevented by mycophenolate mofetil in early experimental diabetic nephropathy

Cytokine
Yonggui WuJijia Shen

Abstract

Several works in the setting of early experimental diabetic nephropathy using anti-inflammatory drugs, such as mycophenolate mofetil (MMF), have shown that prevention of the development or amelioration of renal injury including proteinuria. The exact mechanisms by which anti-inflammatory drugs lower the albuminuria have no still to clarify well. In this study, diabetes was induced by injection of streptozotocin after uninephrectomy. Rats were randomly divided into three groups: control group, diabetic group and diabetic group treated with MMF. Elevated 24h urinary albumin excretion rate was markedly attenuated by MMF treatment. In diabetic rats receiving no treatment, there were increase in ED-1+ cells in the glomeruli, which were effectively suppressed by MMF treatment. The expression of nephrin and podocin protein was reduced in the glomeruli from diabetic rats, and MMF treatment significantly increased the expression of nephrin and podocin. The expression of IL-1, TNF-alpha and 3-NT protein in the glomeruli were significantly increased in diabetic rats, which were all significantly inhibited by MMF treatment. Our results show that MMF could decrease urinary albumin excretion, which mechanism may be at least partly correlated...Continue Reading

References

Mar 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M G SuranyiB D Myers
Nov 30, 1999·Journal of the American Society of Nephrology : JASN·K Tryggvason
Aug 25, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·E C DempseyR O Messing
Oct 29, 2000·Journal of the American Society of Nephrology : JASN·Kevin V LemleyRobert G Nelson
Jul 18, 2001·Current Opinion in Nephrology and Hypertension·K Tryggvason, J Wartiovaara
Aug 18, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D J Nikolic-Paterson, R C Atkins
Sep 14, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·P AaltonenH Holthöfer
Jul 10, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Darren J KellyRichard E Gilbert
Dec 11, 2002·Kidney International·Ricardo UtimuraIrene De Lourdes Noronha
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Klaas KoopJan A Bruijn
Dec 25, 2003·Journal of the American Society of Nephrology : JASN·Marcus J MoellerLawrence B Holzman
May 20, 2004·Kidney International·Ariela BenigniGiuseppe Remuzzi
May 6, 2005·Journal of the American Society of Nephrology : JASN·Katherine R Tuttle
Sep 22, 2005·Nephrology·Nam Ho Kim
Sep 24, 2005·Journal of the American Society of Nephrology : JASN·Kosuke YozaiHirofumi Makino
Sep 29, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Juan F Navarro, Carmen Mora
Dec 1, 2005·Current Diabetes Reports·Carmen Mora, Juan F Navarro
Jan 6, 2006·Journal of the American Society of Nephrology : JASN·Elena Galkina, Klaus Ley
Jan 24, 2006·International Immunopharmacology·Yong-Gui WuShan-Tan Lin

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Citations

Mar 2, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Chunhua ZhuAihua Zhang
Jan 5, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Daniel P K NgHarry Holthöfer
Nov 13, 2009·American Journal of Physiology. Renal Physiology·Sarah F KnightJohn D Imig
Sep 10, 2014·Chemico-biological Interactions·P MuthennaG Bhanuprakash Reddy
Feb 3, 2016·Cytokine·Nehal M Elsherbiny, Mohammed M H Al-Gayyar
Apr 9, 2010·Expert Opinion on Investigational Drugs·Maria Koukoulaki, Dimitrios S Goumenos
Mar 10, 2016·Oxidative Medicine and Cellular Longevity·Abraham Said Arellano-BuendíaHoracio Osorio-Alonso
Nov 15, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·X-M QiY-G Wu
Apr 10, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Duo WuYi-Yu Chen
May 19, 2012·International Immunopharmacology·Eduardo Monguilhott DalmarcoTânia Silvia Fröde
Sep 22, 2015·Acta Pharmacologica Sinica·Yuan-jing GuWei Wei
Aug 20, 2010·Cardiovascular Therapeutics·Ahmed A Elmarakby, Jennifer C Sullivan
Jun 7, 2011·International Immunopharmacology·Xiang-Ming QiJi-Jia Shen
Sep 9, 2015·BioMed Research International·Jung-Woo SeoJu-Young Moon
Nov 7, 2015·Journal of the American Society of Nephrology : JASN·Alejandro R ChadeGene L Bidwell
Jun 18, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Agnes HacklLutz Thorsten Weber
Jun 6, 2014·American Journal of Physiology. Renal Physiology·Yimin YaoIvan A Sammut
Mar 25, 2017·Molecular Medicine Reports·Tao PengZhao Hu

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