"Nephritic flares" are predictors of bad long-term renal outcome in lupus nephritis

Kidney International
G MoroniClaudio Ponticelli

Abstract

We retrospectively analyzed the courses of 70 patients with lupus nephritis followed for 5 to 30 years (median 127 months). Patients survival was 100% at 10 years and 86% at 20 years. The probability of not reaching the end point (persistent doubling of plasma creatinine) was 85% at 10 years and 72% at 20 years. A multivariate analysis of variables at presentation showed that male sex (P = 0.005) and hematocrit lower than 36% (P = 0.01) were associated with the end point (relative risk 7.5 and 14). We then analyzed for the role of renal flare-ups, defined either as a rapid increase in plasma creatinine or by an increase in proteinuria. Patients with renal flares of any type had more probabilities of reaching the end point than patients who never had flares (P = 0.03; relative risk 6.8). The hazard of the end point was 27 times higher in patients with flares along with rapid increased in plasma creatinine than in patients without flares or with flares with proteinuria alone (P < 0.00001). This hazard was higher when plasma creatinine did not return to the basal levels within two months after treatment (P < 0.00001).

References

Oct 1, 1992·Archives of Internal Medicine·M M Ward, S Studenski
Sep 1, 1989·The Journal of Clinical Investigation·A ChagnacB D Myers
Oct 1, 1988·Kidney International·A B MagilR A Sutton
Sep 1, 1983·The American Journal of Medicine·H A AustinJ E Balow
Jun 1, 1982·Arthritis and Rheumatism·S RosnerE V Barnett
Jun 1, 1982·Annals of Internal Medicine·Q Whiting-O'KeefeW V Epstein
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Apr 1, 1980·The Journal of Allergy and Clinical Immunology·S R Hirsch, J H Kalbfleisch
Apr 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J S Cameron
Mar 1, 1994·Arthritis and Rheumatism·J M EsdaileM Kashgarian
Apr 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K IsekiK Fukiyama

❮ Previous
Next ❯

Citations

Feb 28, 2006·Zeitschrift für Rheumatologie·M Aringer, J Smolen
Dec 4, 2012·Zeitschrift für Rheumatologie·M Haubitz
Nov 30, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Byong Sop LeeYong Choi
Apr 17, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Shuichiro FujinagaKazunari Kaneko
Jul 31, 2013·Current Rheumatology Reports·Teresa K Chen, Derek M Fine
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Dimitrios T BoumpasGeorge Bertsias
Aug 30, 2008·Nature Clinical Practice. Rheumatology·George Bertsias, Dimitrios T Boumpas
Dec 22, 2010·Nature Reviews. Nephrology·Vladimir Tesar, Zdenka Hruskova
Nov 14, 2012·Nature Reviews. Nephrology·Ben SprangersGerald B Appel
Mar 29, 2002·Kidney International·Marta MoscaStefano Bombardieri
Sep 24, 1998·The New England Journal of Medicine·D E HricikJ R Sedor
Jun 12, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Josefina Cortés-HernándezJosep Ordi-Ros
Nov 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maria S StoenoiuUNKNOWN MAINTAIN Nephritis Trial Group
Dec 13, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Heather K MorrisGerald B Appel
Apr 11, 2000·Current Opinion in Nephrology and Hypertension·J E Balow, H A Austin
Nov 26, 2013·International Journal of Rheumatic Diseases·Alimohammad FatemiMahdi Moosavi
Jul 9, 2010·Nephrology·Olugbenga Edward AyodeleCharles R Swanepoel
Aug 2, 2012·Annals of the Rheumatic Diseases·George K BertsiasUNKNOWN European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association
Aug 19, 2003·Annals of the Rheumatic Diseases·C C MokK N Lai
Apr 13, 2005·Nephron. Clinical Practice·Jane CrossUNKNOWN Renal Association Clinical Trials Subcommittee
May 19, 2010·Theoretical Biology & Medical Modelling·Paula Budu-GrajdeanuBrad H Rovin
Nov 10, 2010·Arthritis Research & Therapy·Katerina LaskariHaralampos M Moutsopoulos
Nov 3, 2009·Internal Medicine·Yuki TsurutaKosaku Nitta
Nov 16, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Yiann E ChenUNKNOWN Collaborative Study Group
May 3, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Daniel J BirminghamLee A Hebert
Sep 3, 2011·Indian Journal of Nephrology·S K AnnavarajulaC A Narain
Mar 6, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·David AskenaziArundhati Kale
May 18, 2011·Current Rheumatology Reports·Katrina Shum, Anca Askanase
Dec 10, 2014·Expert Review of Clinical Immunology·Gabriella Moroni, Claudio Ponticelli
Mar 1, 2006·Expert Opinion on Investigational Drugs·Felix Braun, Matthias Behrend
Oct 18, 2008·Renal Failure·Gulizar Manga SahinHulya Ergin
Jun 18, 2011·The American Journal of the Medical Sciences·Sandeep SinghRamesh Saxena
Jun 21, 2011·The American Journal of the Medical Sciences·Hala AlshayebElvira O Gosmanova
Nov 15, 2014·Lupus Science & Medicine·G GreloniE R Soriano
Jul 6, 2006·Kidney International·C GrootscholtenUNKNOWN Dutch Working Party on Systemic Lupus Erythematosus
Aug 25, 2006·Kidney International·M Waldman, G B Appel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.