PMID: 7344245Apr 1, 1981Paper

Nephritis and hemolytic anemia in owl monkeys (Aotus trivirgatus)

Veterinary Pathology
L V ChalifouxN W King

Abstract

The two most common diseases of captive owl monkeys (Aotus trivirgatus) are hemolytic anemia and glomerulonephritis. The anemia is characterized by total red blood cell counts between 0.45 and 3.44 x 10(6) microliters, hemoglobin values as low as 1.0 g/dl, and many circulating nucleated red blood cells. Centrilobular necrosis in the liver, extramedullary hematopoiesis in liver and spleen, and hemoglobin casts in kidney tubules are prominent histologic features. Hemosiderin and lipofuscin often are found in liver, spleen, kidney and lymph nodes. Microthrombi and microinfarcts sometimes are scattered throughout the brain. Glomerular lesions in Aotus have been described previously and are characterized by increased numbers of mesangial cells and matrix, glomerulosclerosis and electron dense deposits in basement membranes. Lymphocytes, plasma cells and eosinophils frequently are present in the interstitium. In the early stages the cellular infiltrate is periglomerular. The foci then grow to encompass adjacent glomeruli and tubules. Finally, large portions of the kidney are affected and connective tissue proliferates. The incidence of extramedullary hematopoiesis in the liver correlated significantly with that of interstitial nephri...Continue Reading

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Citations

Feb 1, 1987·Journal of Cutaneous Pathology·R E Mrak, G F Baker
Nov 1, 1987·American Journal of Reproductive Immunology and Microbiology : AJRIM·R B ThauC W Bardin
Apr 19, 2012·American Journal of Primatology·Fernanda Luiza de Miranda Lins e LinsPaulo Henrique Gomes de Castro
Jan 1, 1992·American Journal of Primatology·Richard E WellerHarvey A Ragan
Jan 1, 1980·Acta Neuropathologica·R T BronsonW M Strauss
Dec 22, 2000·Molecular Therapy : the Journal of the American Society of Gene Therapy·T TodoR L Martuza
Jun 16, 2021·ILAR Journal·Chandra SaravananHsi-Yu Yen

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