Nephrocalcinosis in animal models with and without stones.

Urological Research
Saeed R Khan

Abstract

Nephrocalcinosis is the deposition of calcium salts in renal parenchyma and can be intratubular or interstitial. Animal model studies indicate that intratubular nephrocalcinosis is a result of increased urinary supersaturation. Urinary supersaturation with respect to calcium oxalate (CaOx) and calcium phosphate (CaP) are generally achieved at different locations in the renal tubules. As a result experimental induction of hyperoxaluria in animals with CaP deposits does not lead to growth of CaOx over CaP. Interstitial nephrocalcinosis has been seen in mice with lack of crystallization modulators Tamm-Horsfall protein and osteopontin. Sodium phosphate co-transporter or sodiumhydrogen exchanger regulator factor-1 null mice also produced interstitial nephrocalcinosis. Crystals plug the tubules by aggregating and attaching to the luminal cell surface. Structural features of the renal tubules also play a role in crystal retention. The crystals plugging the terminal collecting ducts when exposed to the metastable pelvic urine may promote the formation of stone.

References

Jan 1, 1992·The Journal of Urology·S R KhanR L Hackett
Sep 1, 1989·The Journal of Urology·S R KhanR L Hackett
Nov 21, 1986·JAMA : the Journal of the American Medical Association·R A ConyersA M Rofe
Jan 1, 1983·Urological Research·S R KhanR L Hackett
Mar 1, 1995·The Journal of Urology·S R Khan, P A Glenton
Jan 1, 1997·World Journal of Urology·S R Khan
Jan 1, 1997·Urological Research·J A GokhaleS R Khan
Apr 16, 1998·Urological Research·C HennequinB Lacour
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·L BeckH S Tenenhouse
Apr 9, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R de WaterF H Schröder
Aug 23, 2000·Journal of Endourology·R K LowC K Schreiber
Sep 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A GlauserB Hess
Feb 19, 2002·Kidney International·David A BushinskyFredric L Coe
Aug 15, 2002·Biochemical and Biophysical Research Communications·Susumu KatsumaGozoh Tsujimoto
Aug 24, 2002·Pflügers Archiv : European journal of physiology·Harriet S TenenhouseRené J M Bindels
Dec 31, 2002·Journal of the American Society of Nephrology : JASN·Jeffrey A WessonJeremy Hughes
Mar 6, 2003·The Journal of Clinical Investigation·Andrew P EvanMarc Grynpas
Apr 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hien ChauHarriet S Tenenhouse
Oct 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Franca Serafini-CessiDaniela Cavallone
Feb 10, 2004·The Journal of Urology·Neil S MandelJohn H Wiessner
Feb 24, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Saeed R Khan, Dirk J Kok
Feb 24, 2004·Journal of the American Society of Nephrology : JASN·Tohru UmekawaSaeed R Khan
Jan 28, 2005·Kidney International·Andrew P EvanMarc Grynpas
Feb 16, 2006·Urological Research·Susan Ruth MarengoGregory T MacLennan
May 20, 2006·Kidney International·A P EvanE M Worcester
Jun 16, 2006·Current Opinion in Nephrology and Hypertension·David A BushinskyKeith Nehrke
Jan 4, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Naohiko OkamotoTadaichi Kitamura
Jan 6, 2007·Urological Research·Jennifer C AndersonAndré J Sommer
Feb 1, 2007·Kidney International·A P EvanE Worcester
Jun 1, 1937·Annals of Surgery·A Randall
Sep 28, 2007·American Journal of Physiology. Renal Physiology·Lan MoXue-Ru Wu

❮ Previous
Next ❯

Citations

Mar 12, 2013·World Journal of Urology·Aslam KhanSaeed R Khan
Oct 29, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shrikant R MulayHans-Joachim Anders
Apr 16, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Qiaoli LiJouni Uitto
Apr 24, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Leah K VanWeyJohn F Mustard
Jan 29, 2016·Nature Communications·Shrikant R MulayHans-Joachim Anders
Nov 28, 2012·The Urologic Clinics of North America·Herman Singh BaggaMarshall L Stoller
Mar 26, 2015·Kidney International·Linda ShavitRobert J Unwin
Sep 18, 2014·Kidney International·Xiaojing TangJohn C Lieske
Jan 24, 2012·The Journal of Urology·Saeed R KhanManoj Monga
Jul 1, 2015·Biochimica Et Biophysica Acta·Sunil JoshiSaeed R Khan
Sep 12, 2015·BioMed Research International·Eva Y G De VilderOlivier M Vanakker
Aug 8, 2015·Clinical Kidney Journal·Safa E AlmukhtarMichael D Hughson
Aug 12, 2014·Urolithiasis·Andrew P EvanJames E Lingeman
Aug 15, 2014·Urolithiasis·Saeed R Khan, Benjamin K Canales
Jul 12, 2013·Acta Cirúrgica Brasileira·Natália Baraldi CunhaJoão Luiz Amaro
Dec 18, 2013·Toxicologic Pathology·Susan A ElmoreJerrold M Ward
Apr 21, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Eleanor Lederer, Ken-ichi Miyamoto
May 14, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lukas KonradHans-Joachim Anders
May 18, 2016·Nature Reviews. Disease Primers·Saeed R KhanHans-Göran Tiselius
Jul 13, 2019·Journal of the American Society of Nephrology : JASN·Shrikant Ramesh MulayHans-Joachim Anders
Jul 31, 2019·The Journal of Clinical Investigation·Jacob A TorresThomas Weimbs
Jun 15, 2019·Cell Death & Disease·Giovanna PrianteFranca Anglani
Mar 27, 2019·Journal of Cell Science·Cliff-Lawrence IbehBidhan C Bandyopadhyay
Mar 17, 2020·Kidney International·Pedro Henrique Imenez SilvaCarsten Alexander Wagner
Jan 31, 2021·Nature Reviews. Nephrology·Saeed R KhanPaul R Dominguez-Gutierrez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.