Nephrocalcinosis in rabbits--correlation of ultrasound, computed tomography, pathology and renal function

Pediatric Radiology
B CramerC Pushpanathan

Abstract

Objective. The purpose of this study was to induce nephrocalcinosis (NC) in rabbits with phosphate, vitamin D, oxalate and furosemide, to determine the effect on renal function and to correlate detection on ultrasound (US) and computed tomography (CT) with pathology. Materials and methods. Seventy-five immature New Zealand white rabbits were divided into five groups of 15. In each group, 5 animals were controls and 10 were given oral phosphate, furosemide, vitamin D or oxalate. Unilateral nephrectomy was performed at 3-6 weeks, and 5 rabbits of each test group were withdrawn from the substance. Weekly US was performed as well as US, CT and measurement of serum creatinine at the time of nephrectomy and prior to planned demise. Results. A total of 140 kidneys in 75 rabbits had both pathological and US correlation, with CT correlation in 126. Forty rabbits developed nephrocalcinosis with early (post nephrectomy at 3-6 weeks) or late (post demise at 12-20 weeks) pathological correlation obtained in 53 kidneys. Forty-one of these kidneys were from test animals: 23 developed NC early, 18 late. Twelve controls developed NC: 4 early, 8 late. Comparing US and CT to pathology, the sensitivity was 96% for US, 64% for CT. Specificity was 8...Continue Reading

Citations

Jun 24, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ari Auron, Uri S Alon
Dec 24, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Bernd Hoppe, Markus J Kemper
Aug 26, 1999·Ultrasound in Medicine & Biology·G P KulbiskyR Gordon
Jul 20, 2002·European Journal of Radiology·D D Maudgil, K McHugh
Jan 8, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pietro Manuel FerraroGiovanni Gambaro
Oct 24, 2000·Kidney International·E A Schell-FeithB J van der Heijden
Oct 23, 2001·Archives of Disease in Childhood. Fetal and Neonatal Edition·A NarendraJ Beattie
May 25, 2007·Nephron. Clinical Practice·Lara CheiddeIta Pfeferman Heilberg
Jan 26, 2013·The Journal of Clinical Endocrinology and Metabolism·Alison M BoyceRachel I Gafni
Sep 14, 2010·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Alan DanemanJeffrey Traubici
Sep 18, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Eveline A Schell-FeithAlbert J van der Heijden
Jan 6, 2001·The British Journal of Radiology·E A Schell-FeithA J van der Heijden
Jun 11, 2015·Nephrology·Giorgina Barbara PiccoliAndrea Veltri
Jan 26, 2013·The Veterinary Clinics of North America. Exotic Animal Practice·Frances Margaret Harcourt-Brown
Dec 6, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Y G KimH Y Oh
May 9, 2019·Journal of the Endocrine Society·Guido de Paula Colares NetoRegina Matsunaga Martin
Jan 20, 2021·Néphrologie & thérapeutique·Catherine Monet-DidaillerJérôme Harambat

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved