Nephrogenic systemic fibrosis associated with gadolinium use

Journal of the Formosan Medical Association = Taiwan Yi Zhi
Chi-Chao ChaoSung-Tsang Hsieh

Abstract

Nephrogenic systemic fibrosis (NSF) is an idiopathic, progressive, systemic fibrosis that occurs in patients with renal diseases. Recently, gadolinium-containing contrast (Gd-contrast) has become a suspected causal factor for NFS. This report discusses two female patients with end-stage renal disease, aged 70 and 51 years, respectively, who developed histologically proven NSF after exposure to Gd-contrast. Clinically, both patients were characterized by fibrosis and induration of skin and muscle mainly in the limbs with joint contracture. In the first case, NSF developed gradually after undergoing evaluation by Gd-contrast magnetic resonance imaging (MRI) and subsequent surgery for her urothelial carcinoma. In the second patient, NSF developed after undergoing evaluation by Gd-contrast MRI for her right shoulder bursitis with calcification, and the conditions of NSF continued to worsen after the surgical treatment of this right shoulder lesion. Although the role of Gd-contrast in NSF is still not well known, the correlation in our cases strongly suggests that it should be used with cautioned in patients with end-stage renal disease. Both of our patients underwent surgery before or during the development of NSF, indicating that ...Continue Reading

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Citations

May 17, 2011·Indian Journal of Dermatology·Zhitong Zou, Lin Ma
Apr 24, 2010·The British Journal of Radiology·Y TsushimaH S Thomsen
Nov 7, 2015·Chemistry : a European Journal·Gérald CasterouMyrtil L Kahn
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