Nephrolithiasis as a Risk Factor for CKD: The Atherosclerosis Risk in Communities Study

Clinical Journal of the American Society of Nephrology : CJASN
Andrew E KummerJosef Coresh

Abstract

Previous studies demonstrated a higher risk of CKD in persons with a history of kidney stones, but these studies examined mostly white populations and did not evaluate important potential interactions such as race and plasma uric acid. In 10,678 Atherosclerosis Risk in Communities (ARIC) study participants free of CKD at baseline (ARIC visit 4 in 1996-1998), we assessed the association between a history of nephrolithiasis (a time-varying variable, defined by a combination of self-report and diagnostic codes) and incident CKD (defined by diagnostic codes from linkage to hospitalizations and US Centers for Medicare and Medicaid Services' records). At baseline, 856 participants had a history of nephrolithiasis; 322 developed nephrolithiasis during follow-up. Over a mean follow-up of 12 years, there were 1037 incident CKD events. Nephrolithiasis history was associated with a 29% (hazard ratio [HR], 1.29; 95% confidence interval [95% CI], 1.07 to 1.54) higher risk of CKD in demographic-adjusted analyses, but the association was no longer statistically significant after multivariable adjustment (HR, 1.09; 95% CI, 0.90 to 1.32). The multivariable-adjusted association was stronger among participants with plasma uric acid levels ≤6 mg/d...Continue Reading

References

Apr 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A P EvanJ E Lingeman
May 12, 1990·BMJ : British Medical Journal·F P CappuccioM Mancini
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·M Cirillo, M Laurenzi
Dec 1, 1983·British Journal of Urology·W G RobertsonA Smith
Nov 1, 1982·The American Journal of Clinical Nutrition·J A BaeckeJ E Frijters
Mar 21, 1998·American Journal of Hypertension·F MadoreG C Curhan
Feb 19, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R J JohnsonA B Fogo
Feb 7, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G GambaroA D'Angelo
Aug 23, 2002·Journal of the American Society of Nephrology : JASN·Michelle E Tarver-CarrFrederick L Brancati
Mar 24, 2004·Annals of Epidemiology·Suma VupputuriDale P Sandler
Jan 28, 2005·Kidney International·Daniel L GillenFredric L Coe
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Aug 18, 2005·Kidney International·Eric N TaylorGary C Curhan
Apr 7, 2006·Journal of the American Society of Nephrology : JASN·Mary Ann CameronKhashayar Sakhaee
Dec 13, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·John C LieskeCynthia L Leibson
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Naim M MaaloufKhashayar Sakhaee
Mar 14, 2008·Journal of the American Society of Nephrology : JASN·Daniel E WeinerAndrew S Levey
Sep 19, 2008·Journal of the American Society of Nephrology : JASN·Rudolf P ObermayrRenate Klauser-Braun
Apr 3, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Andrew D RuleJohn C Lieske
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Oct 27, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nathan A SaucierJohn C Lieske
Jul 10, 2010·Journal of the American Society of Nephrology : JASN·Andrew D RuleJohn C Lieske
Jan 22, 2011·The Journal of Urology·Alexander P ReinerMarshall L Stoller
Jun 15, 2011·Urology·Adam O KadlecThomas M T Turk
Jun 30, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Ziad M El-ZoghbyAndrew D Rule
Sep 1, 2012·BMJ : British Medical Journal·R Todd AlexanderUNKNOWN Alberta Kidney Disease Network
Aug 7, 2013·JAMA : the Journal of the American Medical Association·Pietro Manuel FerraroGary C Curhan
Dec 7, 2013·Clinical Journal of the American Society of Nephrology : CJASN·R Todd AlexanderUNKNOWN Alberta Kidney Disease Network
Apr 15, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Morgan E GramsJosef Coresh
Jun 15, 2014·The Journal of Urology·Jonathan ShoagBrian H Eisner
Apr 19, 2015·Arthritis Research & Therapy·Matthew J RoughleyEdward Roddy

❮ Previous
Next ❯

Citations

Aug 16, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Casey M RebholzJosef Coresh
Oct 26, 2016·Mayo Clinic Proceedings·William E HaleyAndrew D Rule
Mar 14, 2017·The Journal of Urology·Giovanni GambaroPietro Manuel Ferraro
Jul 26, 2017·Transplantation·Krista L LentineAmit X Garg
Sep 5, 2017·Investigative and Clinical Urology·Justin B Ziemba, Brian R Matlaga
Mar 25, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fang-Fei WeiJan A Staessen
Dec 16, 2020·Clinical Transplantation·Dina N MuradHassan N Ibrahim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.