Nephron progenitor cell commitment: Striking the right balance

Seminars in Cell & Developmental Biology
Lori L O'Brien

Abstract

The filtering component of the kidney, the nephron, arises from a single progenitor population. These nephron progenitor cells (NPCs) both self-renew and differentiate throughout the course of kidney development ensuring sufficient nephron endowment. An appropriate balance of these processes must be struck as deficiencies in nephron numbers are associated with hypertension and kidney disease. This review will discuss the mechanisms and molecules supporting NPC maintenance and differentiation. A focus on recent work will highlight new molecular insights into NPC regulation and their dynamic behavior in both space and time.

Citations

Apr 13, 2019·International Journal of Molecular Sciences·Kristen KurtzebornSatu Kuure
Aug 14, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Kieran M Short, Ian M Smyth
Apr 12, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Matthew W HarerKimberly J Reidy
Feb 8, 2020·F1000Research·Vladimir M Kozlov, Andreas Schedl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.