PMID: 6146649Aug 1, 1984Paper

Nephropathia epidemica in Norway: antigen and antibodies in rodent reservoirs and antibodies in selected human populations

The Journal of Hygiene
T TraavikJ Dalrymple

Abstract

Nephropathia epidemica (NE) antigen was detected by IFAT (indirect fluorescent antibody technique) in the lungs of 14 of 97 bank voles (Clethrionomys glareolus) collected in three endemic areas. The distribution of antigen positive voles within an endemic location was scattered. Antibodies to Korean hemorrhagic fever (KHF) virus antigens were detected by IFAT in 12 of 14 NE antigen positive bank voles and in 15 of 83 that were antigen negative. NE antigen positive voles exhibited higher antibody titres. Antibodies to KHF were demonstrated in sera from C. rutilus and C. rufocanus collected more than 200 km north of the distribution area for C. glareolus. It appears likely that these vole species can serve as virus vectors for NE cases occurring north of the bank vole area. NE antibodies cross-reacting with KHF virus seem to diminish with time after infection in some NE patients, while for others such cross-reacting antibodies were detected up to 12 years after the disease. Antibodies to KHF were detected in eight of 106 healthy forestry workers with no clinical history of NE. No serological cross-reactions were detected between NE/KHF antigens and representative Bunyaviridae present in Norway. NE/KHF-like viruses appear widespre...Continue Reading

References

Mar 1, 1978·The Journal of Infectious Diseases·H W LeeK M Johnson
Jan 1, 1977·Archives of Virology·T TraavikE Kjeldsberg
Jul 28, 1979·Lancet
Feb 1, 1980·The Journal of Infectious Diseases·M Brummer-KorvenkontioJ Lähdevirta

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Citations

Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·R YanagiharaC J Gibbs
Jul 25, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Lourdes LledóAke Lundkvist
Aug 28, 2010·Vector Borne and Zoonotic Diseases·Gert E OlssonHeikki Henttonen
Jul 11, 2003·Journal of Agromedicine·Douglas J Covert, Ricky L Langley
May 18, 2006·Emerging Infectious Diseases·Peter RabinowitzJoshua Dein
Jan 1, 1988·Scandinavian Journal of Infectious Diseases·A I SommerJ Dalrymple
Oct 12, 2002·Journal of Medical Virology·J KlingströmA Lundkvist
Sep 6, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·C BoehmeM Hoelscher

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