Nephrostomy track brachytherapy following percutaneous resection of transitional cell carcinoma of the renal pelvis

Clinical Oncology : a Journal of the Royal College of Radiologists
S F ShepherdD P Dearnaley

Abstract

Percutaneous nephrostomy can be used to resect transitional cell carcinoma (TCC) from the renal pelvis, to avoid nephrectomy in selected patients. This procedure carries a potential risk of tumour seeding along the nephrostomy track, which it is our policy to irradiate prophylactically. A total of 25 procedures on 23 patients have been carried out since 1982. The 18 males and five females had a median age of 64 years (range 46-81) at the time of treatment. Of the ten patients with only one functioning kidney, nine had undergone contralateral nephroureterectomy, seven for TCC, one for a non-functioning kidney, and one for renal tuberculosis; one patient had received radical radiotherapy for an inoperable contralateral renal tumour. The other 13 patients had asked for a conservative treatment approach to be adopted. From 1982-1989, low dose rate 192Ir wire was used in 13 patients to deliver a median dose of 45 Gy (range 40-50) to the full length of the track at the surface of nephrostomy tube. Since 1989, we have used a high dose rate (HDR) 192Ir microSelectron to treat 12 patients with a single fraction of 10-12 Gy, including two who had undergone previously 192Ir wire track irradiation of the same kidney. One patient required a...Continue Reading

References

May 1, 1978·International Journal of Radiation Oncology, Biology, Physics·B H van der Werf-Messing
Feb 1, 1989·British Journal of Urology·G R MuftiJ P Blandy
May 1, 1982·Urology·B N NocksG R Prout
Jun 1, 1982·The Journal of Urology·K M TomeraH Zincke
Dec 1, 1981·British Journal of Urology·D M WallaceJ E Wickham
May 1, 1980·The Journal of Urology·D M MurphyW L Furlow
Jan 1, 1981·The Journal of Urology·D M MurphyW L Furlow

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Citations

Feb 15, 2001·The Journal of Urology·M DoretG Képénékian
Aug 2, 2005·Journal of Endourology·Ben H ChewJohn D Denstedt
Dec 1, 2000·The Urologic Clinics of North America·D G AssimosJ H Martin

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