Nephrotic syndrome and acute renal failure in non-Hodgkin lymphoplasmacytic lymphoma.

Medical Oncology
Natasa ColovićMilica Colović

Abstract

Two patients with lymphoplasmacytic lymphoma, and monoclonal proteins of IgM in one, and IgG and lambda light chains in the second patient, nephrotic syndrome and acute renal failure are reported. A 58-year-old man previously treated for pre-B acute lymphoblastic leukemia, developed 3 years later nephrotic syndrome as a complication of lymphoplasmacytic lymphoma and high-paraprotein IgM kappa type. Immunofluorescent analysis of kidney biopsy showed extensive IgM and light kappa chain deposits, which caused membranoproliferative glomerulonephritis. Treatment with cyclophosphamide was ineffective and patient died 2 months later. The second patient is a 42-year-old female diagnosed with lymphoplasmacytic lymphoma and paraprotein IgG lambda type. The course of the disease was fulminant with developing nephrotic syndrome and fatal acute renal failure. Immunofluorescent and light microscopic studies of kidney biopsy showed signs of immunotactoid glomerulonephritis with deposits of IgG and C3. Hemodyalises and cytostatic therapy were without response and she died after 45 days.

References

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Citations

Aug 11, 2010·Medical Oncology·José VerdúJosé Antonio Fernández
Feb 16, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jill VanmassenhoveFadi Fakhouri
Jan 14, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nuria S PérezLuis F Quintana
Dec 25, 2012·BMC Nephrology·David KratochvilMaike Büttner
Sep 26, 2013·Renal Failure·Chiara SalvianiAnna Rachele Rocca
Nov 1, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nupur N UppalKenar D Jhaveri

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