PMID: 973Aug 1, 1975

Nephrotic syndrome in indian children

Archives of Disease in Childhood
R N SrivastavaH D Tandon

Abstract

A clinicopathological study of 206 Indian children with nephrotic syndrome showed a primary renal cause in 195 (96%), of which 77% were boys. In 126 children (96 boys, 30 girls) onset of the disorder occurred before the age of 5 years. Renal biopsy showed minimal lesions in 150 patients (77%); in 85 of these biopsy was done 3 months to 16 years after onset of the nephrotic syndrome. Significant renal histological abnormalities in 45 cases were labelled as mesangiocapillary 8, mesangioproliferative 4, proliferative with extensive crescents 2, membranous 3, focal segmental glomerulosclerosis 9, focal global glomerulosclerosis 2, advanced nonspecific 8, and mild proliferative 9. Nephritic manifestations were mainly associated with significant renal lesions, which were more frequently encountered when the onset of disease was after the age of 5 years. Clearance of proteinuria with corticosteroid therapy was practically confined to patients with minimal or mild renal histological changes. Our findings suggest that the pattern of idiopathic nephrotic syndrome in Indian children is similar to that reported from Western countries.

References

Apr 1, 1966·The Journal of Clinical Investigation·K N DrummondR L Vernier
Aug 1, 1969·Archives of Disease in Childhood·Y C TsaoJ B Gibson
Jul 25, 1970·Lancet·J A RichardsonJ Hopper
Jun 27, 1970·Lancet·R H WhiteR J Mills

Citations

Apr 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R N Srivastava
Apr 1, 1989·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M ZakiA F Khalil
May 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R N SrivastavaK R Sunderam
Jan 1, 1996·International Urology and Nephrology·S A al-RasheedM O al-Sohaibani
Jan 1, 1985·Indian Journal of Pediatrics·M S SaberiG Hashemi
Jul 14, 2012·Indian Pediatrics·Aditi SinhaA Bagga
Feb 12, 2013·Indian Pediatrics·R N Srivastava
Jan 1, 1977·Transactions of the Royal Society of Tropical Medicine and Hygiene·A F HallettH M Coovadia
Jan 1, 1980·Transactions of the Royal Society of Tropical Medicine and Hygiene·M S Hutt
May 1, 1994·Acta Paediatrica·Sanjeev GulatiA Gupta
Nov 1, 1985·Archives of Disease in Childhood·P M SharplesR H White
Nov 1, 1985·Archives of Disease in Childhood·J FeehallyJ Walls
Apr 10, 2014·Nigerian Journal of Clinical Practice·P N ObiagwuA T Atanda
Jan 1, 1983·Indian Journal of Pediatrics·V P ChoudhryR A Bhujwala
Jul 29, 2009·Clinical and Experimental Nephrology·Muhammed MubarakSajid Bhatti
Jun 19, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ana Carmen Quaresma MendonçaSérgio Veloso Brant Pinheiro
Dec 1, 1984·Annals of Tropical Paediatrics·A DateJ C Shastry
May 14, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jitendra KumarRamesh Kumar Gupta
Apr 18, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anurag BajpaiRajendra N Srivastava
Sep 1, 1993·Annals of Saudi Medicine·T K Mattoo, A M Al-Sowailem

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