Nephrotic syndrome induced by dibasic sodium phosphate injections for twenty-eight days in rats

Toxicologic Pathology
Noriko TsuchiyaTakane Matsui

Abstract

Sprague-Dawley rats received once daily tail-vein injections of 360 mM dibasic sodium phosphate solution at 8 mL/kg for fourteen or twenty-eight days. Clinical examination revealed persistent proteinuria from three days after the first dosing and thereafter severe proteinuria from eight days or later in the phosphate-treated groups. Proteinuria developed without remission even after fourteen-day withdrawal in the fourteen-day dosed group. Phosphate-treated animals developed lipemia, hypercholesterolemia, anemia, higher serum fibrinogen levels, and lower serum albumin/globulin ratios on day 29. Renal weight increased significantly compared with control animals, and the kidneys appeared pale and enlarged with a rough surface. Histopathologically, glomerular changes consisted of mineralization in whole glomeruli, glomerular capillary dilatation, partial adhesion of glomerular tufts to Bowman's capsule, and mesangiolysis. Ultrastructural lesions such as an increased number of microvilli, effacement of foot processes, and thickening of the glomerular basement membrane, and immunocytochemical changes in podocytes, mainly decreased podoplanin-positive cells and increased desmin expression, were also conspicuous in the phosphate-treate...Continue Reading

References

Sep 1, 1977·CRC Critical Reviews in Toxicology·J E Gray
Jan 1, 1988·Kidney International·A A Eddy, A F Michael
Jun 1, 1988·Kidney International·D B Bernard
Jan 1, 1986·Toxicologic Pathology·C P PeterM J van Zwieten
Jan 1, 1986·Toxicologic Pathology·H A Solleveld, G A Boorman
Jan 1, 1995·Archives of Toxicology·N G ReadA Rowlands
Jan 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Allison A Eddy
Jan 30, 2004·Journal of the American Society of Nephrology : JASN·Hideaki NakajimaEnyu Imai
Jan 30, 2004·Journal of the American Society of Nephrology : JASN·Nigel J Brunskill
Feb 10, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·M L GrossK Amann
Jan 10, 2006·The American Journal of Pathology·Daniela MacconiAndrea Remuzzi
Jan 19, 2006·Virchows Archiv : an International Journal of Pathology·Jun ZouTadashi Yamamoto
Oct 13, 2006·Journal of the American Society of Nephrology : JASN·Mauro AbbateGiuseppe Remuzzi
Sep 22, 2007·Metabolism: Clinical and Experimental·Choong H KimNosratola D Vaziri

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Citations

Mar 20, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Wagner de Fátima PereiraAna Cristina Simões E Silva

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Methods Mentioned

BETA
x-ray microanalysis
scanning electron microscopy
dissection
electron microscopy
light microscopy

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