PMID: 186169Oct 1, 1976Paper

Nephrotoxic and cytoproliferative effects of streptozotocin: report of a patient with multiple hormone-secreting islet cell carcinoma

Cancer
R L MyerowitzT Cavallo

Abstract

The nephrotoxic and cytoproliferative side effects observed in a patient with Streptozotocin-treated, multiple hormone-secreting, pancreatic islet cell carcinoma are described. Streptozotocin induced prolonged partial remission of the patient's multiendocrine syndrome but resulted in progressive azotemia, which was controlled by temporary hemodialysis. A renal biopsy, the first to be reported in detail in such a condition, demonstrated a tubulo-interstitial nephritis and a glomerular alteration consisting of cellular nodules. At autopsy there were numerous bilateral renal cortical spindle cell "tumors" and cellular aggregates in glomeruli. These findings suggest that the tumorigenic effects of Streptozotocin demonstrated in animals may also occur in man.

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Citations

Mar 29, 2002·Kidney International·Jan MelinBengt C Fellström
Jan 1, 1980·Drug and Chemical Toxicology·B S LevineE Rosen
Jul 1, 1981·Kidney International
Mar 1, 1983·Pathology, Research and Practice·H Wehner, M Petri
Oct 1, 1981·The American Journal of Medicine·M F FerF A Greco
Jan 1, 1984·The Anatomical Record·A P EvanF C Luft
Jul 1, 1984·The Journal of Urology·I D GoldbergW D Bloomer

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