Nephrotoxicity: a rational approach to target cell injury in vitro in the kidney

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
P H Bach, E N Kwizera


1. The kidney is a complex organ in which there is cellular heterogeneity. Many nephrotoxic chemicals target preferentially for discrete cell types, but adjacent, morphologically different cells are unaffected. This selectivity has made the assessment of nephrotoxicity in vivo (and the study of underlying mechanisms) difficult. Discrete renal injury can, however, be exploited in vitro, to study the interactions between the toxic compound and the target cell. 2. Several in vitro models have been used to study the potential interaction between the target cells and chemicals, including perfusion of the isolated kidney, renal slices, freshly isolated fragments, primary cultures and continuous cell lines. Where appropriate, isolated organelles and purified enzymes can also be used. 3. The target cell toxicity in vivo of adriamycin, 2-bromoethanamine and hexachlorobutadiene N-acetyl cysteine conjugate is selectively maintained towards glomerular epithelial, medullary interstitial and proximal tubular cells, respectively, in vitro, showing that the "in vivo-in vitro gap" can be bridged. Characteristics unique to each of these renal cell types, such as the selective uptake of a toxin, enzyme systems for generating biologically reactive...Continue Reading


Dec 1, 1978·Clinical Science and Molecular Medicine. Supplement·B D Ross
Dec 1, 1979·Kidney International·T V ZenserB B Davis
Nov 1, 1976·Toxicology and Applied Pharmacology·F J Koschier, W O Berndt
Jun 1, 1976·Environmental Health Perspectives·W O Berndt
Sep 15, 1977·Biochemical Pharmacology·F J Koschier, W O Berndt
Jan 1, 1979·Toxicology and Applied Pharmacology·J S WoldB L Miller
Aug 1, 1979·Toxicology and Applied Pharmacology·E A Lock, J Ishmael
Jun 1, 1979·Metabolism: Clinical and Experimental·K S RothS Segal
Jun 15, 1979·The Biochemical Journal·H Meisner, P Selanik
Feb 1, 1977·Toxicology and Applied Pharmacology·W O Berndt
Feb 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J R FryJ W Bridges
Jul 1, 1978·Kidney International·J I KreisbergM J Karnovsky
Jul 1, 1978·Toxicology and Applied Pharmacology·W M Kluwe, J B Hook
Jul 14, 1978·Biochemical and Biophysical Research Communications·P MoldéusS Orrenius
Dec 1, 1978·Kidney International·G BaverelM Pellet
Apr 1, 1975·Toxicology and Applied Pharmacology·W O Berndt
May 1, 1986·Archives of Toxicology·E A LockP Ormond
Jan 1, 1985·Critical Reviews in Toxicology·P H Bach, J W Bridges
Jun 1, 1967·The Biochemical Journal·J M Nishiitsutsuji-UwoH A KREBS
Apr 1, 1982·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·J C RichardsonN L Simmons
May 1, 1982·The Journal of Cell Biology·D A HerzlingerG K Ojakian
Mar 11, 1981·The American Journal of Physiology·M H Saier
Feb 1, 1981·Journal of Cellular Physiology·M Taub, M H Saier
Mar 1, 1983·Kidney International·J I Kreisberg, M J Karnovsky
Sep 30, 1983·Toxicology and Applied Pharmacology·J H Smith, J B Hook
Nov 30, 1982·Biochimica Et Biophysica Acta·U Zimmermann
Jan 1, 1980·The International Journal of Biochemistry·J SraerR Ardaillou
Jan 1, 1981·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K R EmslieJ Tange
May 1, 1981·European Journal of Biochemistry·P MoldéusD J Reed
May 1, 1981·Kidney International·D AlcornJ Tange
Jan 1, 1981·Methods in Enzymology·K OrmstadD P Jones
Jan 1, 1981·Methods in Enzymology·J F Newton, J B Hook
Jan 1, 1980·The International Journal of Biochemistry·G K RaddaM Lowry
Jul 1, 1980·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R ElbersH Rabes
Nov 1, 1963·Journal of Applied Physiology·A W BAUMANE M MILES

Related Concepts

Medicinal Plants Testing, Preclinical

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

Related Papers

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
P A MeredithJ L Reid
European Journal of Applied Physiology and Occupational Physiology
G B MeeseM I Lewis
Toxicology in Vitro : an International Journal Published in Association with BIBRA
H V SheeversA J Gandolfi
© 2021 Meta ULC. All rights reserved