Nephrotoxicity associated with amphotericin B deoxycholate in neonates

The Pediatric Infectious Disease Journal
Jennifer LeJay M Lieberman

Abstract

The prevalence of nephrotoxicity in neonates receiving amphotericin B deoxycholate (amphoB) is not well-defined. While some studies report a lack of toxicity, others claim a frequency as high as 85%. We reviewed medical records of all infants < or = 90 days of age in the neonatal intensive care unit who received at least 3 doses of amphoB between January 1990 and December 2004. A standardized form was used to collect demographic, therapeutic, microbiologic, and laboratory data for each patient. Nephrotoxicity was defined as a rise in serum creatinine (SCr) of at least 0.4 mg/dL any time during amphoB therapy. A total of 92 infants met entry criteria. Median gestational age was 26 (range: 23-41) weeks and median birth weight was 863 (range: 546-4000) grams. Overall, 15 (16%) infants experienced nephrotoxicity, and 16 (17%) developed hypokalemia (<3.0 mmol/L). There were no differences between infants who did or did not develop nephrotoxicity in terms of gestational age, birth weight, gender, underlying medical conditions, or use of other potentially nephrotoxic medications. AmphoB exposure and duration of therapy were similar between infants who developed nephrotoxicity and those who did not, with a mean cumulative dose of 13.5 ...Continue Reading

References

Mar 1, 1990·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·R Sabra, R A Branch
Jan 1, 1990·The Pediatric Infectious Disease Journal·K M ButlerC J Baker
Feb 1, 1985·American Journal of Diseases of Children·R B TurnerJ O Hendley
Dec 1, 1993·Southern Medical Journal·C GlickS Feldman
Nov 5, 1997·The Pediatric Infectious Disease Journal·A R KingoD Waisman
Jul 9, 1998·The Pediatric Infectious Disease Journal·E H KossoffM G Karlowicz
Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M FernandezC J Baker
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J H RexJ E Edwards
Mar 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D W BatesR Platt
Nov 14, 2001·The American Journal of Medicine·S HarbarthM H Samore
Mar 15, 2002·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Denise GravelGary Garber
Dec 10, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stephan HarbarthMatthew H Samore
Apr 23, 2004·Drugs·Daniel A C FrattarelliJacob V Aranda
Jul 14, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrew J UllmannUNKNOWN Longitudinal Evaluation of Antifungal Drugs (LEAD I) Investigators
Nov 8, 2008·The Pediatric Infectious Disease Journal·Priya A PrasadTheoklis E Zaoutis
Feb 5, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasUNKNOWN Infectious Diseases Society of America

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Citations

Dec 25, 2012·Current Opinion in Pediatrics·Beatriz Larru, Theoklis E Zaoutis
Aug 27, 2014·Clinics in Perinatology·Jennifer G Jetton, David J Askenazi
Apr 7, 2015·Expert Opinion on Pharmacotherapy·Lorena Botero-CalderonMichael Cohen-Wolkowiez
Jun 2, 2010·Current Medical Research and Opinion·David A Kaufman
Jul 3, 2013·Early Human Development·Jessica EricsonDaniel K Benjamin
Feb 22, 2012·Clinics in Perinatology·Daniela TestoniDaniel K Benjamin
Sep 15, 2015·Current Opinion in Pharmacology·Virginia Ramos-MartínWilliam Hope
Mar 24, 2015·Journal of Pediatric Urology·L L de WallT P V M de Jong
Feb 14, 2015·Clinics in Perinatology·Kelly C Wade, Heather M Monk
Aug 4, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A H Groll, A Tragiannidis
Mar 13, 2014·The Pediatric Infectious Disease Journal·David F BesElvira Arrizurieta
Mar 30, 2018·The Pediatric Infectious Disease Journal·Daniel K BenjaminThomas J Walsh
Jan 30, 2010·Expert Review of Anti-infective Therapy·Cornelia Lass-Flörl
Jan 25, 2018·The Journal of Pharmacy and Pharmacology·Chirlie Silver, Sara Rostas
Feb 9, 2011·Current Opinion in Infectious Diseases·Anna TurkovaMike Sharland
Mar 23, 2011·Expert Review of Anti-infective Therapy·Necdet Kuyucu
Jun 9, 2020·Expert Opinion on Drug Metabolism & Toxicology·Briana L ScottKanecia Zimmerman
Mar 1, 2019·Clinical Microbiology Reviews·Renáta TóthAttila Gácser
Aug 26, 2020·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Jenna W BartlettRitu Banerjee
Feb 5, 2021·Clinical Pharmacology and Therapeutics·Kevin J Downes, Jennifer L Goldman

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