Abstract
Medication-induced nephrotoxicity remains one of the most common causes of acute kidney injury (AKI) among hospitalized patients. Within the extensive group of medications associated with AKI, antibiotics and other antimicrobials are well recognized triggers of structural and functional renal impairment. Clinical manifestations range from mild forms of tubular injury to significant deterioration of kidney function requiring acute renal replacement therapy. Several mechanisms are described, although the most frequent are acute interstitial nephritis, acute tubular necrosis, intratubular crystal deposition, and proximal/distal tubulopathy with electrolyte wasting abnormalities. General risk factors for antimicrobial-induced AKI include pre-existing chronic kidney disease, and concomitant use of medication with nephrotoxic potential. Prevention and early recognition of AKI represent the standard approach to mitigate AKI and avoid morbidity.
Citations
Jun 6, 2020·Journal of Clinical Medicine·Joana GameiroJosé António Lopes
Oct 28, 2020·Environmental Toxicology·Sawsan M El-SonbatyMustafa M M Elbakry
Jan 1, 2021·Oxidative Medicine and Cellular Longevity·Marwan AlmoiliqyYuan Lin
Mar 4, 2021·Internal and Emergency Medicine·Angela P Cornelius, Katherine Weigartz
Mar 20, 2021·International Urology and Nephrology·Bahia Chahine
Apr 2, 2021·Journal of Medical Virology·Seyed Majid Mousavi MovahedHoomaan Ghasemi
Apr 24, 2021·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Lucas Alexandre de Mello GoldinVinicius Daher Alvares Delfino
May 1, 2021·Antibiotics·Daniel Florin PancuCristina Dehelean
May 1, 2021·Pharmaceuticals·Aurelija M GrigonyteAndrew Millard
May 23, 2021·The Journal of Antimicrobial Chemotherapy·Shawn H MacVaneRomney M Humphries
Jun 15, 2021·Frontiers in Cellular and Infection Microbiology·Man WangXiaorong Hu
Jul 3, 2021·International Journal of Molecular Sciences·Ewa KwiatkowskaSebastian Kwiatkowski
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·José M Cela-LópezVicente Martínez
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Noureddine BencheikhMostafa Elachouri
Oct 28, 2021·Drug and Chemical Toxicology·Ismail Necati HakyemezEren Altun
Oct 30, 2021·Current Medical Research and Opinion·Phuc LeMichael B Rothberg