Nephrotoxicity of Antimicrobials and Antibiotics

Advances in Chronic Kidney Disease
Martha Catalina Morales-Alvarez

Abstract

Medication-induced nephrotoxicity remains one of the most common causes of acute kidney injury (AKI) among hospitalized patients. Within the extensive group of medications associated with AKI, antibiotics and other antimicrobials are well recognized triggers of structural and functional renal impairment. Clinical manifestations range from mild forms of tubular injury to significant deterioration of kidney function requiring acute renal replacement therapy. Several mechanisms are described, although the most frequent are acute interstitial nephritis, acute tubular necrosis, intratubular crystal deposition, and proximal/distal tubulopathy with electrolyte wasting abnormalities. General risk factors for antimicrobial-induced AKI include pre-existing chronic kidney disease, and concomitant use of medication with nephrotoxic potential. Prevention and early recognition of AKI represent the standard approach to mitigate AKI and avoid morbidity.

Citations

Jun 6, 2020·Journal of Clinical Medicine·Joana GameiroJosé António Lopes
Jan 1, 2021·Oxidative Medicine and Cellular Longevity·Marwan AlmoiliqyYuan Lin
Mar 4, 2021·Internal and Emergency Medicine·Angela P Cornelius, Katherine Weigartz
Apr 24, 2021·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Lucas Alexandre de Mello GoldinVinicius Daher Alvares Delfino
Jul 3, 2021·International Journal of Molecular Sciences·Ewa KwiatkowskaSebastian Kwiatkowski
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·José M Cela-LópezVicente Martínez
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