PMID: 9438663Jan 23, 1998Paper

Nephrotoxicity of beta-lactam antibiotics: mechanisms and strategies for prevention

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
B M Tune

Abstract

The nephrotoxic beta-lactam antibiotics cause acute proximal tubular necrosis. Significant renal toxicity, which has been rare with the penicillins and uncommon with the cephalosporins, is a greater risk with the penems. Mechanisms of injury include: (1) transport into the tubular cell, mainly through the antiluminal organic anion secretory carrier; (2) acylation of target proteins, causing respiratory toxicity by inactivation of mitochondrial anionic substrate carriers; and (3) lipid peroxidation. The most nephrotoxic beta-lactams available for study are cephaloridine, cephaloglycin, and imipenem; panipenem, which is comparably nephrotoxic, is currently available only in Japan. Cephaloridine has several unique properties, probably all caused by its pyridinium side-group: (1) its secretory transport into the tubular cell is followed by minimal cell to luminal fluid movement, resulting in extreme intracellular sequestration; (2) it is the only beta-lactam shown to cause significant oxidative injury; (3) it has a limited ability to attack the mitochondrial carriers for pyruvate and the short-chain fatty anions. Cephaloglycin and imipenem undergo less intracellular trapping than cephaloridine, but have sufficient tubular cell upta...Continue Reading

Citations

Oct 9, 2002·Medicinal Research Reviews·Guofeng You
Jan 30, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ludwig Patzer
Jan 25, 2007·Pharmaceutical Research·Ahsan N Rizwan, Gerhard Burckhardt
Sep 13, 2008·Archives of Pharmacal Research·Sung-Chul LimHyo-Kyung Han
Dec 6, 2011·Archives of Pharmacal Research·Hyo-Kyung Han
Sep 18, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Giulia BenedettiMarjo de Graauw
Mar 23, 2002·European Journal of Pharmacology·Michio TakedaHitoshi Endou
Mar 26, 2003·European Journal of Pharmacology·Suparat KhamdangHitoshi Endou
Jul 5, 2013·Science Translational Medicine·Sameer KalghatgiJames J Collins
Dec 5, 2006·Biological & Pharmaceutical Bulletin·Hiroshi SaitohHitoshi Sekikawa
Aug 29, 2014·Pediatric Research·Ruud R G BuetersMichiel F Schreuder
Feb 21, 2014·Journal of Pharmacology & Pharmacotherapeutics·Mossad Gamaleddin Ahmed ElsayedMohamed Elbadawy
Sep 7, 2006·Drug Development and Industrial Pharmacy·D R TaftI A Savant
Jun 12, 2010·Expert Opinion on Drug Metabolism & Toxicology·Junya Nagai, Mikihisa Takano
Jun 8, 2013·Pharmacological Reports : PR·Jianghao YeKexin Liu
Dec 1, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C WeilandH Ellinger-Ziegelbauer
Sep 17, 2013·Pediatric Blood & Cancer·Jennifer A PrattMichael J Burke
Apr 6, 2005·The Journal of Pharmacy and Pharmacology·Hye-Sun GwakHyo-Kyung Han
Feb 26, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Jakub Zieg, Jaromir Hacek
Apr 23, 2005·Toxicology and Applied Pharmacology·Douglas H Sweet
May 3, 2008·Chemico-biological Interactions·Lorena PochiniCesare Indiveri
Jan 5, 2002·Journal of Chemotherapy·V Fanos, L Cataldi
Feb 21, 2007·Journal of Chemotherapy·V FanosM Testa
May 21, 2005·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M S Ghuysen
Sep 29, 2011·Journal of Chemical Information and Modeling·Masataka TakarabeMinoru Kanehisa
Oct 27, 2016·Biochemical Pharmacology·Çiğdem Yılmaz, Gülay Özcengiz
Aug 2, 2017·Antimicrobial Agents and Chemotherapy·Sarah E CotnerDavid S Burgess
Oct 23, 2018·Expert Opinion on Drug Metabolism & Toxicology·Julia PletzMark T D Cronin
Jan 11, 2019·The Journal of Toxicological Sciences·Sung Ha RyuKyu-Bong Kim
Jan 4, 2008·Journal of Applied Toxicology : JAT·Hiromi SuzukiTohru Inoue
Dec 16, 2005·The Journal of Biological Chemistry·Satish A EralySanjay K Nigam
Jul 9, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Guohua AnMarilyn E Morris
Oct 5, 2016·Clinical Medicine : Journal of the Royal College of Physicians of London·Ben OliveiraAine Burns
Apr 3, 2020·Expert Opinion on Drug Safety·Carla BastidaAntoni Torres
Apr 30, 2016·Oncotarget·Edwardine LabayRalph R Weichselbaum
Aug 16, 2003·Current Opinion in Nephrology and Hypertension·Satish A EralySanjay K Nigam
Feb 24, 2004·Molecular Pharmacology·Satish A EralySanjay K Nigam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.