PMID: 3764322Jan 1, 1986Paper

Nephrotoxicity of hexachlorobutadiene and its glutathione-derived conjugates

Toxicologic Pathology
J Ishmael, E A Lock

Abstract

The nephrotoxicity of hexachloro-1,3-butadiene (HCBD), its glutathione conjugate (HCBD-GSH), cysteine conjugate (HCBD-CYS), and its N-acetyl cysteine conjugate (HCBD-NAC) were compared in male and female Alderley Park rats. Rats, six to eight weeks of age, were given a single intra-peritoneal injection of HCBD or its conjugates and killed 24 hours later. Nephrotoxicity was assessed by histological examination and plasma urea. All three glutathione-derived conjugates produced an elevation of plasma urea and proximal renal tubular necrosis with a similar localization in the pars recta as seen with HCBD. All the conjugates were more nephrotoxic than HCBD itself. HCBD was about four times more toxic to female rats than males. This sex difference was also shown by all the HCBD metabolites.

References

Jan 1, 1983·Toxicology and Applied Pharmacology·J B HookE A Lock

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Citations

Apr 1, 1988·Archives of Toxicology·K FentG Zbinden
Apr 1, 1996·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H E HaenenP J Van Bladeren
Mar 12, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·M T Boroushaki
Oct 15, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G J IkedaI A Ross
Feb 1, 2003·Toxicology Letters·Trevor GreenJames Hill
Apr 20, 2004·Journal of Occupational Health·Mithat BakoğluSavaş Ayberk
Jul 10, 2012·Expert Opinion on Drug Metabolism & Toxicology·Andrea TrevisanPatrizia Cristofori
Feb 11, 2015·Cell Biology and Toxicology·Patrizia CristoforiAndrea Trevisan
Mar 18, 2020·Journal of Medicinal Chemistry·Benjamin M JohnsonNicholas A Meanwell

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