NERD: an umbrella term including heterogeneous subpopulations

Nature Reviews. Gastroenterology & Hepatology
Edoardo SavarinoVincenzo Savarino

Abstract

Nonerosive reflux disease (NERD) represents the more common phenotypic presentation of GERD and comprises patients who have typical symptoms without any mucosal breaks at endoscopy. However, these patients are markedly heterogeneous from a pathophysiological point of view and should be correctly classified by means of 24 h impedance-pH testing, which enables detection of both acidic and weakly acidic reflux and correlation with symptoms. This technique is able to identify two subsets of NERD (that is, patients with an excess of acid or with a hypersensitive oesophagus to both acid and weakly acidic reflux) and patients with functional heartburn (who do not have any kind of reflux underlying their symptoms and must be excluded from the realm of GERD). The mechanisms of symptom generation are not clear in patients with NERD, but the presence of microscopic oesophagitis, including the dilation of intercellular spaces, seems to have a relevant role. Patients with NERD in whom acid is the main pathogenetic factor respond successfully to PPI therapy, while those with hypersensitive oesophagus to weakly acidic reflux need to be treated with reflux inhibitors or surgery, although the experience in this field is very scant. Patients wit...Continue Reading

References

Oct 26, 1995·The New England Journal of Medicine·S VigneriA Pilotto
Aug 13, 1999·The American Journal of Gastroenterology·A J Cameron
Jan 12, 2000·Digestive Diseases and Sciences·C Prakash, R E Clouse
Jun 10, 2000·Alimentary Pharmacology & Therapeutics·K G MandelH I Jacoby
Mar 21, 2001·Bulletin du cancer·B LacourUNKNOWN Groupe Information médicale de la Fédération nationale des centres de lutte contre le cancer
Aug 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·N PehlivanovR K Mittal
Mar 21, 2002·Journal of Gastroenterology and Hepatology·K AdachiY Kinoshita
Apr 13, 2002·Advances in Experimental Medicine and Biology·R Waldmann
Jul 4, 2002·The American Journal of Gastroenterology·Philip MinerSheldon Sloan
Feb 4, 2003·Alimentary Pharmacology & Therapeutics·P ZentilinV Savarino
Mar 8, 2003·Alimentary Pharmacology & Therapeutics·S D MartinezR Fass
Jul 24, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Weibiao CaoKaren M Harnett
Aug 4, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Bonnie B DeanRonnie Fass
Oct 6, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P ZentilinV Savarino
Mar 4, 2005·The American Journal of Gastroenterology·Carlo CalabreseGiulio Di Febo
Mar 15, 2005·Gastroenterology·William J Barlow, Roy C Orlando
Feb 8, 2006·European Journal of Gastroenterology & Hepatology·Yasser M Bhat, Klaus Bielefeldt
Feb 17, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P ZentilinV Savarino
Apr 22, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M FrazzoniV Savarino
May 9, 2006·Gastroenterology·Jean Paul GalmicheAndre J P M Smout

❮ Previous
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Citations

Jul 13, 2013·Surgical Endoscopy·Edoardo SavarinoVincenzo Savarino
Aug 10, 2013·Clinical Oral Investigations·Andrea OttonelloEdoardo Savarino
Nov 19, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·Edoardo SavarinoVincenzo Savarino
Jan 11, 2014·World Journal of Gastroenterology : WJG·Pietro Dulbecco, Vincenzo Savarino
Jan 28, 2014·Journal of Neurogastroenterology and Motility·Edoardo SavarinoVincenzo Savarino
May 3, 2014·Surgical Endoscopy·Karl Hermann FuchsUNKNOWN European Association of Endoscopic Surgery (EAES)
Aug 2, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Edoardo SavarinoChiara de Cassan
Sep 25, 2014·Human Pathology·Manuele FurnariEdoardo Savarino
Dec 15, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I MartinucciN de Bortoli
Sep 13, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·N de BortoliS Marchi
Jul 1, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marzio FrazzoniVincenzo Savarino
Sep 13, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Nicola de BortoliSantino Marchi
Jan 31, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Takashi KondoHiroto Miwa
Jan 18, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I MartinucciS Marchi
Nov 19, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R SweisM Fox
Aug 1, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S ToloneE Savarino
Dec 18, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·N de BortoliS Marchi
Dec 3, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Fong-Kuei F ChengFouad J Moawad
May 27, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S ToloneE Savarino
Dec 17, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nicola de BortoliSantino Marchi
Jul 6, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Pim W WeijenborgAlbert J Bredenoord
May 5, 2016·Gastroenterology·Qasim AzizFrank Zerbib
Sep 21, 2013·Gut·Edoardo SavarinoVincenzo Savarino
Jul 1, 2016·The American Journal of Gastroenterology·Edoardo SavarinoVincenzo Savarino
Oct 28, 2016·Annals of the New York Academy of Sciences·Jan MartínekGeorge Triadafilopoulos
Aug 4, 2016·Nature Reviews. Gastroenterology & Hepatology·Kornilia NikakiDaniel Sifrim
Sep 7, 2016·Expert Opinion on Pharmacotherapy·Edoardo SavarinoVincenzo Savarino
Sep 14, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M FrazzoniE Savarino
Jul 23, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Edoardo SavarinoRoberto Penagini
Sep 21, 2016·The American Journal of Gastroenterology·Nicola de BortoliSantino Marchi
Oct 28, 2016·Annals of the New York Academy of Sciences·Edoardo SavarinoEllen Stein
Nov 7, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M RibolsiM Cicala
Oct 8, 2016·Revista de gastroenterología de México·R Soto-SolísM A Ballesteros-Amozurrutia
Oct 28, 2016·European Journal of Internal Medicine·Vincenzo SavarinoEdoardo Savarino
Nov 9, 2016·BMC Medicine·Carmelo ScarpignatoUNKNOWN Italian Society of Pharmacology, the Italian Association of Hospital Gastroenterologists, and the Italian Federation of Gene
Oct 28, 2016·Annals of the New York Academy of Sciences·Nicola de BortoliEdoardo Savarino
Jan 10, 2017·Revista de gastroenterología de México·S Sobrino-CossíoJ M Remes-Troche
May 26, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L FrazzoniE Savarino
Mar 25, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R O SilvaM H L P Souza
Sep 7, 2017·Nature Reviews. Gastroenterology & Hepatology·Edoardo Savarino, Marco Della Coletta
Sep 28, 2017·Nature Reviews. Gastroenterology & Hepatology·Edoardo SavarinoUNKNOWN International Working Group for Disorders of Gastrointestinal Motility and Function
May 17, 2018·Annals of the New York Academy of Sciences·Junichi AkiyamaGeorge Triadafilopoulos

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