Abstract
Nerolidol, an acyclic sesquiterpene found as a major constituent of several essential oils, has several pharmacological activities, but its action in pain processes has never been studied. The purpose of our research was to evaluate the antinociceptive and anti-inflammatory activities of nerolidol, as well as possible mechanisms of action, in experimental mouse models of pain. Antinociceptive activity was evaluated using the acetic acid-induced writhing test, the formalin test, and the hot-plate test. The nerolidol-treated group showed lesser acetic acid-induced abdominal contractions than the control group in all of the three doses tested (200, 300, and 400 mg/kg, p.o.). The formalin test doses of 300 and 400 mg/kg p.o. inhibited licking time, in both the first phase and the second phase. In the hot-plate test, nerolidol did not alter latency at any of the observed time points. Motor coordination, evaluated through the rotarod test, was not hindered in animals treated with nerolidol. Regarding the mechanism of action, the antinociceptive activity of nerolidol is related to the GABAergic system, and not to the opioidergic or ATP-sensitive K(+) channels. Treatment with nerolidol reduced carrageenan-induced paw edema. In the mode...Continue Reading
References
Aug 1, 1992·British Journal of Pharmacology·H RogersA G Hayes
Jan 1, 1991·Carcinogenesis·L W Wattenberg
Jun 1, 1985·Journal of Neuroscience Methods·S HunskaarK Hole
Dec 24, 1997·Journal of Ethnopharmacology·M JavanM Kamalinejad
Jan 15, 1998·Gastroenterology·J C HallC Platell
Jul 7, 1999·Lancet·C R Chapman, J Gavrin
Jan 16, 2003·Immunology Letters·Foo Y Liew
Mar 1, 1957·Journal of the American Pharmaceutical Association·N W DUNHAM, T S MIYA
Jan 1, 1997·European Journal of Pain : EJP·G M Green, A Dickenson
Apr 28, 2005·Antimicrobial Agents and Chemotherapy·Denise C ArrudaSilvia R B Uliana
Aug 10, 2007·Proceedings of the National Academy of Sciences of the United States of America·Colleen R McNamaraChristopher M Fanger
Jun 28, 2008·Pain·John D Loeser, Rolf-Detlef Treede
Oct 20, 2009·Cell·Allan I BasbaumDavid Julius
Feb 10, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D McGintyA M Api
Mar 30, 2010·Pharmacology, Biochemistry, and Behavior·K VidyalakshmiS Ramaswamy
Jun 12, 2010·Journal of Ethnopharmacology·Ana Cristina TavaresLígia Ribeiro Salgueiro
Oct 20, 2010·Basic & Clinical Pharmacology & Toxicology·Enoch Kumar PerimalMohd Roslan Sulaiman
Nov 23, 2010·Journal of Applied Toxicology : JAT·Fernanda PículoEdson Luis Maistro
Jan 11, 2011·Basic & Clinical Pharmacology & Toxicology·Azam Shah MohamadMohd Roslan Sulaiman
Mar 29, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Reinaldo Nóbrega de AlmeidaDamião Pergentino de Sousa
Sep 1, 2011·Journal of Ethnopharmacology·Lidiane OrlandiAlexandre Giusti-Paiva
Oct 6, 2011·Journal of Ethnopharmacology·B G PinheiroP J C Sousa
Oct 13, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Augusto Lopes SoutoJosé Maria Barbosa Filho
Feb 22, 2012·Fundamental & Clinical Pharmacology·Walter Mendes de Oliveira JúniorReinaldo Nóbrega de Almeida
Mar 13, 2012·International Journal of Molecular Sciences·Anderson Marques de OliveiraEmiliano Barreto
Apr 25, 2012·The AAPS Journal·C SchnakersS Laureys
May 17, 2012·Journal of Ethnopharmacology·Daniella K S LimaAdair Roberto Soares Santos
Jul 4, 2012·The Journal of Nutritional Biochemistry·Chi-Chang HuangLie-Fen Shyur
Jun 15, 2013·Neurochemical Research·José Damasceno Nogueira NetoRivelilson Mendes de Freitas
Oct 10, 2013·Fundamental & Clinical Pharmacology·Renan O SilvaJand Venes R Medeiros
Mar 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcos P N SilvaJosué de Moraes
Dec 17, 2014·Biological Research for Nursing·Mohd Hijaz Mohd SaniZainul Amiruddin Zakaria
Mar 17, 2015·Journal of Ethnopharmacology·Idris Ajayi OyemitanMoses Atanda Akanmu
Citations
May 3, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Weng-Keong ChanBey-Hing Goh
Oct 21, 2016·Indian Journal of Pharmacology·Rajesh Kumar GoelPriyanka Pahwa
Aug 24, 2016·BMC Neuroscience·Hayate JavedM Emdadul Haque
Feb 23, 2017·Pharmaceutical Biology·Stefano Dall'AcquaFilippo Maggi
Jan 18, 2017·Phytotherapy Research : PTR·Lu ZhangMinghao Guo
Mar 4, 2017·Basic & Clinical Pharmacology & Toxicology·Bruna Isabela BiaziMário Sérgio Mantovani
Dec 14, 2017·International Journal of Molecular Sciences·Rita de Cássia da Silveira E SáDamião Pergentino de Sousa
May 8, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Rauf MelekogluNese Basak
Apr 19, 2018·Fundamental & Clinical Pharmacology·Marwa Y SallamMahmoud M El-Mas
Jul 18, 2019·Drug Development Research·Loordhurani AsaikumarGanapathi Sindhu
Jul 2, 2019·The Korean Journal of Pain·Faraz Mahdian DehkordiMoosa Javdani
Apr 23, 2020·Natural Product Research·Marabel RiesmeierThibaut Devièse
Sep 18, 2020·BioFactors·Ashif IqubalSyed Ehtaishamul Haque
May 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ze-Jun Wang, Thomas Heinbockel
Dec 11, 2019·Biomolecules·Diogo Vilar da FonsêcaDamião Pergentino de Sousa
Jun 21, 2020·Antioxidants·Ekaterina ProshkinaAlexey Moskalev
Apr 11, 2020·Biomedicines·Millena S CordeiroThais B S Giorno
Aug 25, 2019·Environmental Science and Pollution Research International·Luana QuassintiMassimo Bramucci
Jul 12, 2020·Nutrients·Vishnu RajSandeep B Subramanya
Dec 13, 2019·Oxidative Medicine and Cellular Longevity·Yung-Lun NiYu-Hsiang Kuan
Oct 4, 2020·Pharmaceuticals·Nattaporn Pattarachotanant, Tewin Tencomnao
Nov 13, 2020·Life Sciences·Eloísa Portugal Barros Silva Soares de SouzaAdriano Antunes de Souza Araújo
Sep 18, 2020·Experimental Neurology·Ashif IqubalSyed Ehtaishamul Haque
Nov 20, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yueh-Min LinChih-Yang Huang
Jan 24, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Eric Aian P SilvaMárcio R V Santos
Feb 23, 2021·Toxicology Research·Amandeep KaurPuneet Kumar
Apr 9, 2020·Journal of Ethnopharmacology·Margareth Mello BrandenburgMichel Fleith Otuki
May 18, 2020·Behavioural Brain Research·Shahin HassanpourSeyyed Mojtaba Razavi
Jun 26, 2021·Journal of Agricultural and Food Chemistry·M F Nagoor MeeranShreesh Ojha
Jul 3, 2021·Antioxidants·Seenipandi ArunachalamShreesh Ojha
May 18, 2021·Molecular and Cellular Biochemistry·Salim M A BastakiShreesh Ojha
Nov 13, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Eloísa Portugal Barros Silva Soares de SouzaAdriano Antunes de Souza Araújo
Sep 15, 2019·Life Sciences·Ashif IqubalSyed Ehtaishamul Haque