PMID: 11344820May 10, 2001Paper

Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion

The Israel Medical Association Journal : IMAJ
M HiriartM C Sánchez-Soto

Abstract

Trophic factors such as nerve and fibroblast growth factors are important modulators of beta cell physiology. These two factors induce the extension of neurite-like processes in primary cultures of adult rat beta cells. Moreover, both NGF and FGF enhance glucose-induced insulin secretion. Since beta cells synthesize NGF and pancreatic islet cells produce FGFs, it is possible that autocrine/paracrine interactions may be major regulators of insulin secretion, and impairment of these interactions could lead to pathological states such as diabetes mellitus.

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