Nerve cell injury in the brain of stroke-prone spontaneously hypertensive rats

Acta Neuropathologica
K FredrikssonY Olsson

Abstract

The brain lesions in stroke-prone spontaneously hypertensive rats (SHRSP) are characterized by multifocal microvascular and spongy-cystic parenchymal alterations particularly in the gray matter. An essential feature of the lesions is the presence of edema with massive extravasation of plasma constituents as evidenced by specific gravity measurements, Evans blue technique and immunohistochemistry. The nerve cell injury occurring in the brain lesions in SHRSP is further characterized by light and electron microscopy in the present study. Two types of neuronal changes were seen within the blood-brain barrier (BBB) leakage sites. A small number of neurons with dark condensed nucleus and cytoplasm were found most often at the periphery of recent lesions. The majority of injured neurons were pale and showed intracellular edema confined to the dendrites and perikarya sparing axons and synapses. Their nuclei were well preserved with finely dispersed chromatin. The swollen and watery cell processes of neurons and astrocytes gave a spongy appearance to the neuropil. The intracellular edema seemed to result in cytolysis. The results suggest that primary anoxia-ischemia is not the major pathogenetic mechanism behind the nerve cell injury i...Continue Reading

References

Jan 1, 1976·Stroke; a Journal of Cerebral Circulation·Y YamoriM Fukase
Feb 1, 1986·Annals of Neurology·S M Rothman, J W Olney
Nov 1, 1986·Stroke; a Journal of Cerebral Circulation·M NedergaardJ Astrup
Jan 1, 1985·Acta Neuropathologica·K FredrikssonB B Johansson
May 1, 1972·Journal of the Neurological Sciences·A W Brown, J B Brierley
Jan 1, 1983·Acta Neuropathologica·G EbhardtW D Heiss

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Citations

Feb 14, 1994·Neuroscience Letters·B HasselF Fonnum
Feb 1, 1994·Neuropathology and Applied Neurobiology·C NordborgB B Johansson
Mar 19, 2013·Experimental & Translational Stroke Medicine·Stefanie SchreiberHolger Braun
Dec 23, 2014·Future Neurology·Paco S Herson, Richard J Traystman
Jun 24, 2008·Electromagnetic Biology and Medicine·Henrietta NittbyLeif G Salford
Apr 7, 2009·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Henrietta NittbyLeif G Salford
May 21, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David W HowellsMalcolm R Macleod
Jun 21, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Sandeep AnkolekarPhilip M W Bath
Apr 2, 2002·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Cenk Ayata, Allan H Ropper
Jul 16, 1999·Clinical and Experimental Pharmacology & Physiology·B B Johansson

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