Nerve damage in Mycobacterium ulcerans-infected mice: probable cause of painlessness in buruli ulcer

The American Journal of Pathology
Masamichi GotoHajime Saito

Abstract

Buruli ulcer is an emerging chronic painless skin disease found in the tropics and caused by Mycobacterium ulcerans; however, it remains unknown why the large and deep ulcers associated with this disease remain painless. To answer this question, we examined the pathology of BALB/c mice inoculated in the footpads with M. ulcerans African strain 97-107. On days 54 to 70 after inoculation, extensive dermal ulcers, subcutaneous edema, and numerous acid-fast bacilli were noted at the inoculate region. Nerve invasion occurred in the perineurium and extended to the endoneurium, and some nerve bundles were swollen and massively invaded by acid-fast bacilli. However, Schwann cell invasion, a characteristic of leprosy, was not observed. Vacuolar degeneration of myelin-forming Schwann cells was noted in some nerves which may be induced by mycolactone, a toxic lipid produced by M. ulcerans. Polymerase chain reaction analysis of microdissected nerve tissue sections showed positive amplification of M. ulcerans-specific genomic sequences but not of Mycobacterium leprae-specific sequences. Behavioral tests showed decrease of pain until edematous stage, but markedly ulcerated animals showed ordinary response against stimulation. Our study sugge...Continue Reading

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Citations

Dec 17, 2008·Nature Reviews. Microbiology·Caroline DemangelStewart T Cole
Mar 17, 2011·Nihon Hansenbyō Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association·Junichiro EnMasamichi Goto
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Apr 30, 2019·Frontiers in Pharmacology·Jérémie BabonneauLaurent Marsollier

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Buruli ulcer is a progressive disease of subcutaneous tissues caused by mycobacterium ulcerans. Here is the latest research.