Nerve excitability assessment in chemotherapy-induced neurotoxicity.

Journal of Visualized Experiments : JoVE
Susanna B ParkM C Kiernan

Abstract

Chemotherapy-induced neurotoxicity is a serious consequence of cancer treatment, which occurs with some of the most commonly used chemotherapies(1,2). Chemotherapy-induced peripheral neuropathy produces symptoms of numbness and paraesthesia in the limbs and may progress to difficulties with fine motor skills and walking, leading to functional impairment. In addition to producing troubling symptoms, chemotherapy-induced neuropathy may limit treatment success leading to dose reduction or early cessation of treatment. Neuropathic symptoms may persist long-term, leaving permanent nerve damage in patients with an otherwise good prognosis(3). As chemotherapy is utilised more often as a preventative measure, and survival rates increase, the importance of long-lasting and significant neurotoxicity will increase. There are no established neuroprotective or treatment options and a lack of sensitive assessment methods. Appropriate assessment of neurotoxicity will be critical as a prognostic factor and as suitable endpoints for future trials of neuroprotective agents. Current methods to assess the severity of chemotherapy-induced neuropathy utilise clinician-based grading scales which have been demonstrated to lack sensitivity to change...Continue Reading

References

Aug 22, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·D BurkeH Bostock
Aug 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefano CascinuGiuseppina Catalano
May 10, 2005·Muscle & Nerve·Arun V KrishnanMatthew C Kiernan
Feb 14, 2006·Seminars in Oncology·Frederick H HausheerFrank Lieberman
Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Arun V KrishnanMatthew C Kiernan
Jan 24, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susanna B ParkMatthew C Kiernan
Aug 25, 2009·Progress in Neurobiology·Arun V KrishnanMatthew C Kiernan
Sep 12, 2009·Brain : a Journal of Neurology·Susanna B ParkMatthew C Kiernan
Apr 12, 2011·The Oncologist·Susanna B ParkMatthew C Kiernan

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Citations

Jun 4, 2014·PloS One·Delphine BoërioWerner J Z'Graggen
Aug 12, 2014·Journal of Computational Neuroscience·Mathieu LachanceBéla Joós
Dec 25, 2013·Clinical Colorectal Cancer·Ahmed Hussein ZedanOle Jakob Vilholm
Sep 4, 2015·Cerebellum & Ataxias·William Huynh, Matthew C Kiernan
Jun 22, 2017·Oncology Nursing Forum·Haryani HaryaniYu-Yun Hsu
Aug 30, 2017·World Journal of Clinical Oncology·Ozkan KanatBurcu Caner
Mar 7, 2020·Muscle & Nerve·Kristine BennedsgaardNanna B Finnerup
May 31, 2020·Cancers·Guido Cavaletti, Paola Marmiroli
May 23, 2019·Expert Opinion on Drug Metabolism & Toxicology·Paola Alberti
Aug 7, 2021·Journal of Personalized Medicine·Roser VelascoAndreas A Argyriou

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