Nerve fibre studies in skin biopsies in peripheral neuropathies. I. Immunohistochemical analysis of neuropeptides in diabetes mellitus.

Journal of the Neurological Sciences
M LindbergerH Link

Abstract

Standardised skin biopsies followed by immunohistochemical examination for the presence of terminal nerve fibres reacting for neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) were evaluated. Healthy subjects regularly displayed free nerve endings of both fibre types in the papillary and reticular dermis. Both fibre types were present close to blood vessels, while CGRP immunoreactive fibres were more often encountered near sweat gland acini compared to SP fibres. Diabetes mellitus complicated by polyneuropathy was accompanied by marked reduction of SP and CGRP reactive fibres in the dermis layers. Five type I diabetes patients without clinical or neurophysiological evidence of polyneuropathy also had reduced density of both fibre types, being significant for CGRP fibres when compared with controls. Skin biopsy with immunohistochemical staining for neuropeptides may represent a sensitive tool in evaluation of patients with peripheral neuropathies.

References

Jan 1, 1988·Acta Neuropathologica·S Walter, H H Goebel
Aug 1, 1988·Muscle & Nerve·H D SchrøderH Link
Jun 1, 1988·Acta Neurologica Scandinavica·G Solders
Aug 1, 1984·Journal of the Neurological Sciences·C Ceuterick, J J Martin
Jan 1, 1981·Journal of Immunological Methods·G D Johnson, G M Nogueira Araujo
Nov 8, 1958·Nature·C C CURTAIN

❮ Previous
Next ❯

Citations

May 21, 2013·European Journal of Pharmacology·Vinay KantDinesh Kumar
May 22, 2003·Progress in Neurobiology·Hitoshi YasudaRyuichi Kikkawa
Jan 14, 2009·Expert Reviews in Molecular Medicine·Leena PradhanAristidis Veves
Aug 13, 2011·Expert Reviews in Molecular Medicine·Asma EjazLeena Pradhan
Jun 1, 1996·Nature Medicine·P AnandD V Sinicropi
Jul 27, 2001·Diabetes Technology & Therapeutics·A I VinikK B Stansberry
Dec 1, 2001·Journal of Clinical Neuromuscular Disease·L JohannsenS H Sindrup
Oct 30, 2001·Experimental Neurology·J R TonraP S DiStefano
Aug 27, 2010·Expert Opinion on Biological Therapy·Lucília da SilvaMaria Teresa Cruz
Aug 26, 2006·The Journal of Physiology·Tanja SchlerethFrank Birklein
Dec 18, 2002·The Journal of Investigative Dermatology·MarcosA AntezanaJohnE Olerud
Apr 4, 2008·Acta histochemica·Kristina K BeiswengerAndrew P Mizisin
Aug 15, 2009·Diabetes/metabolism Research and Reviews·Clare Y L Chao, Gladys L Y Cheing
Jul 22, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jeffrey R ScottNicole S Gibran
Sep 14, 1999·The American Journal of Medicine·J C Arezzo
May 22, 2013·Expert Opinion on Emerging Drugs·Francesco TecilazichAristidis Veves
Jan 19, 2011·Expert Opinion on Pharmacotherapy·Francesco TecilazichAristidis Veves
Jul 27, 2001·Diabetes Care·A I VinikG L Pittenger
Oct 31, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Michelle L SpennyNicole S Gibran
Oct 16, 2014·Neural Regeneration Research·Hong JiangHuaying Cai
Jun 2, 2011·Annals of Plastic Surgery·Kasandra R Hanna, Adam J Katz
Aug 9, 2019·Current Osteoporosis Reports·Alec T BeeveErica L Scheller
Dec 4, 2019·Autonomic Neuroscience : Basic & Clinical·Georgios Theocharidis, Aristidis Veves
May 25, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Nicole C NowakAmy S Paller
Sep 18, 2021·The International Journal of Lower Extremity Wounds·Shealinna Ge, Amor Khachemoune

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.