Nerve function and regeneration in diabetic and galactosaemic rats: antioxidant and metal chelator effects

European Journal of Pharmacology
A LoveN E Cameron

Abstract

Immature rats were made diabetic with streptozotocin or were fed a 40% galactose diet to stimulate the polyol pathway. Separate diabetic and galactosaemic groups were treated with butylated hydroxytoluene or trientine. After 4 weeks the sciatic nerve was freeze-lesioned. Two weeks later, the degree of myelinated fibre regeneration was assessed electrophysiologically and nerve conduction velocity was measured in the contralateral leg. Similar sciatic motor and saphenous sensory nerve conduction velocity deficits of approximately 18% and 19%, respectively, compared to age-matched control rats were found in both models. They were partially prevented by treatment (approximately 68% for butylated hydroxytoluene and 63% for trientine). There were 12% and 10% deficits in nerve regeneration distance with diabetes and galactosaemia respectively, which were markedly attenuated (approximately 80%) by both treatments. The data emphasise the importance of elevated, free radical activity for the aetiology of neural/neurovascular deficits in experimental diabetes and galactosaemia.

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Citations

Jul 12, 2002·Diabetes/metabolism Research and Reviews·P Sytze van Dam
Aug 12, 1999·European Journal of Pharmacology·D A GreeneE L Feldman
Dec 28, 1999·European Journal of Pharmacology·J NémethZ Szilvássy
Dec 10, 1999·Diabetes Research and Clinical Practice·N E Cameron, M A Cotter
Feb 20, 2003·Brain Research. Molecular Brain Research·Fang Cai, Cinda J Helke
May 22, 2003·Progress in Neurobiology·Hitoshi YasudaRyuichi Kikkawa
Oct 6, 2000·Reproductive Toxicology·G LiuC L Hughes
Jun 27, 2001·Free Radical Biology & Medicine·N E CameronM A Cotter
Sep 1, 2001·Environmental Toxicology and Pharmacology·M D ColemanC J Bailey
Jun 6, 2013·Journal of Medicinal Food·Si Oh Kim, Hyun Jee Kim
May 8, 2009·Bioscience, Biotechnology, and Biochemistry·Kyoji YoshinoKunimasa Koga
Jan 22, 2005·European Journal of Pharmacology·Peter HorvathZoltan Szilvassy
Dec 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Irina G ObrosovaCsaba Szabó
Apr 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Judith SzilvássyZoltán Szilvássy

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