Nerve growth factor affects passive avoidance learning and retention in developing mice

Brain Research Bulletin
L RicceriG Calamandrei

Abstract

The present studies investigate the effects of early nerve growth factor (NGF) administration on the ontogenetic profile of learning and retention capacities in mice. The learning paradigm used required the animals to withhold an escape response from a vibrating platform to avoid a punishment (step-down passive avoidance). In Experiment 1, acquisition of step-down passive avoidance was essentially the same in 11- and 15-day-old mice whereas only the latter showed significant retention after 24 h. In younger animals, data pointed to a facilitating effect of familiarization with the test environment. In Experiment 2 ICV NGF treatment on postnatal day 9 increased step-down latencies in both reinforced and nonreinforced pups on day 11. Moreover, NGF mice exposed in nonreinforcement condition on day 11 failed to acquire the avoidance response 24 h later, suggesting that the treatment anticipated the appearance of latent inhibition. Results of Experiment 3, investigating the effects of different durations of preexposure to the test apparatus on passive avoidance acquisition 24 h later, supported the specificity of NGF effects on the emergence of latent inhibition. These findings suggest that neural populations responsive to NGF troph...Continue Reading

References

Apr 1, 1978·Journal of Comparative and Physiological Psychology·D Ray, Z M Nagy
May 1, 1976·Developmental Psychobiology·J F Brennan, R J Barone
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L GarofaloA C Cuello
Aug 19, 1991·Brain Research. Developmental Brain Research·G CalamandreiE Alleva
Dec 1, 1991·Brain Research Bulletin·E GouldL L Butcher
Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·P A Lapchak, F Hefti
Nov 1, 1990·Psychological Bulletin·I Weiner
May 1, 1989·Developmental Psychobiology·J S Miller, N E Spear
Sep 4, 1987·Science·R Levi-Montalcini
May 1, 1972·Psychological Review·B A Campbell, N E Spear
Jun 1, 1973·Psychological Bulletin·R E Lubow
Oct 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·V Bocchini, P U Angeletti
May 1, 1982·Pharmacology, Biochemistry, and Behavior·G J SmithN E Spear
Jul 1, 1980·Developmental Psychobiology·D J Stehouwer, B A Campbell
Nov 1, 1994·Trends in Neurosciences·R J Rylett, L R Williams
Aug 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·I B Black
Jul 1, 1994·Neurochemistry International·W Fischer
Jun 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·E S BachmanC F Hohmann

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Citations

Jun 14, 2002·Physiology & Behavior·Marco FioreLuigi Aloe
Apr 1, 1997·Pharmacology, Biochemistry, and Behavior·G CalamandreiA Valanzano
Oct 19, 2002·Behavioural Brain Research·Gemma CalamandreiLaura Ricceri
Sep 2, 2008·Biological & Pharmaceutical Bulletin·Koichiro MoriNorimichi Nakahata
Jan 25, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R WalzI Izquierdo
Feb 14, 1998·Toxicology and Industrial Health·E AllevaD Santucci

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