Nerve growth factor improves visual loss in childhood optic gliomas: a randomized, double-blind, phase II clinical trial

Brain : a Journal of Neurology
Benedetto FalsiniRiccardo Riccardi

Abstract

Paediatric optic pathway gliomas are low-grade brain tumours characterized by slow progression and invalidating visual loss. Presently there is no strategy to prevent visual loss in this kind of tumour. This study evaluated the effects of nerve growth factor administration in protecting visual function in patients with optic pathway glioma-related visual impairment. A prospective randomized double-blind phase II clinical trial was conducted in 18 optic pathway glioma patients, aged from 2 to 23 years, with stable disease and severe visual loss. Ten patients were randomly assigned to receive a single 10-day course of 0.5 mg murine nerve growth factor as eye drops, while eight patients received placebo. All patients were evaluated before and after treatment, testing visual acuity, visual field, visual-evoked potentials, optic coherence tomography, electroretinographic photopic negative response, and magnetic resonance imaging. Post-treatment evaluations were repeated at 15, 30, 90, and 180 days Brain magnetic resonance imaging was performed at baseline and at 180 days. Treatment with nerve growth factor led to statistically significant improvements in objective electrophysiological parameters (electroretinographic photopic negati...Continue Reading

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Citations

Mar 26, 2016·Brain : a Journal of Neurology·Dimitri M Kullmann
Apr 29, 2018·Journal of Neuroscience Research·Morgan E Freret, David H Gutmann
Oct 2, 2019·Documenta Ophthalmologica. Advances in Ophthalmology·Gonzalo OrtizRadouil Tzekov
Apr 11, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Antonio ChiarettiGiorgio Conti
Nov 1, 2016·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Neil R Miller
May 14, 2019·Journal of Cellular Physiology·Chen XieHongwei Wang
Jan 30, 2021·Neural Regeneration Research·Gemma EftimiadiAntonio Chiaretti
Mar 2, 2021·Seminars in Ophthalmology·Levi N Kanu, Joseph B Ciolino

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