Nerve growth factor induces increased airway inflammation via a neuropeptide-dependent mechanism in a transgenic animal model of allergic airway inflammation

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
D QuarcooA Braun

Abstract

Nerve growth factor (NGF) exerts an important functional impact on the pathogenesis of allergic diseases. Data obtained in animal models of allergic bronchial asthma indicate that NGF alters sensory nerve function and promotes allergic inflammation, bronchial hyper-reactivity, and airway obstruction. To further delineate the effects of NGF on airway inflammation, we employed a transgenic (tg) animal model of allergic inflammation and asthma. NGF-tg mice, which overexpress NGF in Clara cells of the airways, were compared with wild-type (wt) littermates regarding their ability to mount IgE-related airway inflammatory responses. Mice were sensitized intraperitoneally to ovalbumin (OVA) and locally challenged via the airways according to established protocols. NGF-tg mice displayed enhanced levels of OVA-specific IgE antibody titres after repeated OVA aerosol exposure. In the airways, increased numbers of eosinophils were detected. These results were confirmed to be NGF specific, because similar results were obtained following local application of NGF into the airways of wt mice. The effect of NGF was partly mediated via neuropeptides, as treatment of OVA-sensitized NGF-tg mice with the dual neurokinin (NK) receptor NK-1/NK-2 antag...Continue Reading

References

Oct 1, 1992·The Journal of Allergy and Clinical Immunology·K NieberG Kunkel
Dec 1, 1988·British Journal of Pharmacology·D F RogersP J Barnes
Jan 1, 1988·Respiration; International Review of Thoracic Diseases·N CrimiA Mistretta
May 1, 1989·Journal of Neuroscience Research·B MorganJ R Perez-Polo
Jan 1, 1987·Journal of Neuroscience Research·L W Thorpe, J R Perez-Polo
Jun 1, 1994·Journal of Neuroimmunology·C Brodie, E W Gelfand
Mar 1, 1994·Journal of Neuroimmunology·E M Kudlacz, R W Knippenberg
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·P B EhrhardU Otten
May 1, 1996·British Journal of Haematology·A HamadaH Matsuda
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·S BoniniL Aloe
Feb 26, 1998·American Journal of Respiratory Cell and Molecular Biology·G W HoyleM Friedman
Dec 16, 1998·American Journal of Respiratory and Critical Care Medicine·J C VirchowA Braun
Apr 24, 1999·Neuroimmunomodulation·V H van der Velden, A R Hulsmann
May 4, 1999·International Archives of Allergy and Immunology·B J UndemA Fischer
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·A de VriesF P Nijkamp
Jul 28, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M SchuilingH Meurs
Sep 30, 1999·American Journal of Respiratory Cell and Molecular Biology·A BraunH Renz
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·A M SanicoA Togias
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·D D HunterB J Undem
Apr 18, 2001·International Archives of Allergy and Immunology·A BraunH Renz
Jul 21, 2001·American Journal of Respiratory and Critical Care Medicine·R M GrahamG W Hoyle
Sep 17, 2002·American Journal of Respiratory and Critical Care Medicine·Günter PäthHarald Renz

❮ Previous
Next ❯

Citations

Jul 31, 2007·Advances in Therapy·Jun Tao FengXiao Zhao Li
Apr 22, 2005·Current Allergy and Asthma Reports·Christina NassensteinHarald Renz
May 19, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Norah G VerboutAllison D Fryer
Jan 1, 2005·American Journal of Respiratory Cell and Molecular Biology·Wataru ItoMitsune Tanimoto
Sep 13, 2006·Environmental Health Perspectives·Kara R SchmelzerBruce D Hammock
Apr 10, 2014·Molecular Therapy. Nucleic Acids·Yi-Lien ChenBor-Luen Chiang
Apr 4, 2012·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Aleksandra SzczepankiewiczMonika Dmitrzak-Węglarz
Dec 16, 2011·The Journal of Allergy and Clinical Immunology·Melissa DullaersBart N Lambrecht
Oct 8, 2011·Immunology and Allergy Clinics of North America·Stuart M Brooks, I Leonard Bernstein
Oct 13, 2009·Pharmacology & Therapeutics·Julie Nasra, Maria G Belvisi
Aug 25, 2007·The Journal of Allergy and Clinical Immunology·Christina NassensteinArmin Braun
Oct 5, 2007·Pharmacology & Therapeutics·V Freund-Michel, N Frossard
Jul 13, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R ChaudhuriN C Thomson
Jun 23, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Q T DinhA Fischer
Dec 12, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R A JoachimB F Klapp
May 24, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Stephen T Holgate
Sep 12, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A de VriesA Fischer
Nov 26, 2009·European Journal of Pain : EJP·Jing YangYanqing Li
Apr 18, 2006·Respiratory Physiology & Neurobiology·Radhika KajekarCharles G Plopper
Feb 7, 2006·European Journal of Pharmacology·Christina NassensteinArmin Braun
Nov 29, 2005·Pathologie-biologie·V Freund-Michel, N Frossard
Sep 6, 2005·Medical Hypotheses·Jun Tao Feng, Cheng Ping Hu
Jul 12, 2011·Biochemical and Biophysical Research Communications·Masataka OdaJun Sakurai
Apr 4, 2007·International Journal of Occupational Medicine and Environmental Health·Tadeusz HałatekJacek Gruchała
Aug 24, 2013·Journal of Occupational and Environmental Medicine·Stuart M Brooks
Jul 22, 2006·Biochemical Society Transactions·C NassensteinA Braun
Aug 24, 2013·Journal of Applied Physiology·Fuad M BaroodyRobert M Naclerio
Apr 19, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ryan E TomlinsonThomas L Clemens
Jan 18, 2006·Clinical Science·Shelley J Allen, David Dawbarn
Oct 22, 2020·The Journal of Biological Chemistry·Cherry WongtrakoolBum-Yong Kang
Jan 18, 2021·The Journal of Biological Chemistry·Cherry WongtrakoolBum-Yong Kang

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