PMID: 9636218Jun 24, 1998Paper

Nerve growth factor inhibits sympathetic neurons' response to an injury cytokine

Proceedings of the National Academy of Sciences of the United States of America
A M ShadiackRichard E Zigmond

Abstract

Axonal damage to adult peripheral neurons causes changes in neuronal gene expression. For example, axotomized sympathetic, sensory, and motor neurons begin to express galanin mRNA and protein, and recent evidence suggests that galanin plays a role in peripheral nerve regeneration. Previous studies in sympathetic and sensory neurons have established that galanin expression is triggered by two consequences of nerve transection: the induction of leukemia inhibitory factor (LIF) and the reduction in the availability of the target-derived factor, nerve growth factor. It is shown in the present study that no stimulation of galanin expression occurs following direct application of LIF to intact neurons in the superior cervical sympathetic ganglion. Injection of animals with an antiserum to nerve growth factor concomitant with the application of LIF, on the other hand, does stimulate galanin expression. The data suggest that the response of neurons to an injury factor, LIF, is affected by whether the neurons still receive trophic signals from their targets.

References

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Citations

Jun 30, 2000·Clinical and Experimental Pharmacology & Physiology·J Kurek
May 25, 2011·Molecular Medicine·Prithi Rajan
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Cheil MoonGabriele V Ronnett
Apr 4, 2008·Neuroscience Letters·T Jarred EwertBeth A Habecker
Jan 20, 2007·Progress in Neurobiology·Ferdinando RossiLuigi Corvetti
Mar 13, 2009·Developmental Neurobiology·Beth A HabeckerRichard E Zigmond
Feb 21, 2006·Neuropeptides·Qi MeiGerald J Taborsky
Jul 9, 2013·Molecular and Cellular Neurosciences·Michael J Pellegrino, Beth A Habecker
Mar 1, 2011·Brain Research·Yan Ping ZhangRoberta Brambilla
Sep 23, 2014·Neuroscience·A DeFrancesco-LisowitzR E Zigmond
Nov 28, 2002·Diabetes·Cees J TackDavid S Goldstein
Aug 25, 2009·Experimental Neurology·Ida Rishal, Mike Fainzilber
Jul 24, 2007·Progress in Neurobiology·X NavarroAntoni Valero-Cabré
Jul 29, 2006·Brain Research Reviews·Josef TrogerEduard Schmid
Sep 30, 2003·Journal of Neuroscience Research·Brian D ArmstrongJames A Waschek
Oct 5, 2020·The European Journal of Neuroscience·Valerio MagnaghiAlessandro Faroni

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