Nerve growth factor is a potential therapeutic target in breast cancer

Cancer Research
Eric AdriaenssensHubert Hondermarck

Abstract

We show here that nerve growth factor (NGF), the prototypic neurotrophin, can be targeted in breast cancer to inhibit tumor cell proliferation, survival, and metastasis. Analysis of a series of biopsies revealed widespread expression of NGF in the majority of human breast tumors, with anti-NGF immunoreactivity concentrated in the epithelial cancer cells. Moreover, immunodeficient mice xenografted with human breast cancer cells and treated with either anti-NGF antibodies or small interfering RNA against NGF displayed inhibited tumor growth and metastasis. Such treatments directed against NGF induced a decrease in cell proliferation with a concomitant increase in apoptosis of breast cancer cells and an inhibition of tumor angiogenesis. Together, these data indicate that targeting NGF in breast cancer may have therapeutic ramifications.

References

Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·L M McGregorB D Nelkin
Feb 22, 2000·The Journal of Biological Chemistry·E TagliabueS Ménard
Oct 2, 2001·Cancer Investigation·M AragonaF La Torre
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Scott Krygier, Daniel Djakiew
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Giuseppina CantarellaRenato Bernardini
Aug 29, 2003·Oncogene·Laurent DolléHubert Hondermarck
Oct 19, 2004·Cancer Cell·Antonella TacconelliAndrew R Mackay
Oct 21, 2005·The New England Journal of Medicine·Harold J Burstein

❮ Previous
Next ❯

Citations

Sep 25, 2008·Clinical & Experimental Metastasis·Cimona V HintonHava Karsenty Avraham
May 30, 2012·Nature Reviews. Rheumatology·Paul I Mapp, David A Walsh
Jul 3, 2008·Anti-cancer Drugs·Hildegard M Schuller
Feb 15, 2013·Journal of Virology·Wondimagegnehu M TeferiDavid H Evans
Jul 14, 2011·Molecular Cancer Therapeutics·Yi YeBrian L Schmidt
Jun 24, 2010·Molecular Cancer·Rodrigue RomonXuefen Le Bourhis
Oct 26, 2013·RNA·Keerthana KrishnanNicole Cloonan
Mar 20, 2008·The American Journal of Pathology·Hubert Hondermarck
Mar 12, 2010·World Journal of Gastroenterology : WJG·Naoaki SakataEba Hathout
Aug 28, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S Kaur, P Bajwa
Aug 25, 2012·Future Medicinal Chemistry·Áron Roxin, Gang Zheng
Dec 25, 2009·Breast Cancer Research and Treatment·Xuefen Le BourhisHubert Hondermarck
Aug 22, 2008·Journal of Cancer Research and Clinical Oncology·Ali Naderi, Luke Hughes-Davies
Feb 18, 2016·Cellular and Molecular Life Sciences : CMLS·Valérie ChopinXuefen Le Bourhis
Jul 4, 2012·Cytokine & Growth Factor Reviews·Hubert Hondermarck
Apr 10, 2012·The Journal of Pain : Official Journal of the American Pain Society·Yi YeBrian L Schmidt
Apr 19, 2011·The Journal of Pain : Official Journal of the American Pain Society·Aaron P BloomPatrick W Mantyh
Jan 12, 2010·Cytokine & Growth Factor Reviews·Federica MarchesiPaola Allavena
Oct 7, 2014·The American Journal of Pathology·Jay PundavelaHubert Hondermarck
Jun 2, 2009·Cancer·Catherine LiebigDaniel Albo
Dec 8, 2010·Proteomics. Clinical Applications·Chann LagadecXuefen Le Bourhis
Dec 11, 2014·Advances in Biological Regulation·Ralph A BradshawHubert Hondermarck
Feb 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·He-da ZhangJin-hai Tang
May 28, 2011·Biochimica Et Biophysica Acta·Mario MancinoVanessa Almendro
Jul 16, 2014·Frontiers in Physiology·Kurt A SchalperMauricio P Oyarzo
Jun 7, 2016·Biochimica Et Biophysica Acta·Ihsan Ekin DemirGüralp O Ceyhan
Aug 5, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Shunsuke TsuzukiYusuke Shiozawa
Sep 1, 2016·Biochemical and Biophysical Research Communications·Reka ChakravarthyAdrienne M Gorman
Sep 23, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Beibei XinXiaohong Shen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis