Nerve growth factor is required for early follicular development in the mammalian ovary

Endocrinology
G A DissenS R Ojeda

Abstract

Nerve growth factor (NGF) epitomizes a family of proteins known as the neurotrophins (NTs), which are required for the survival and differentiation of neurons within both the central and peripheral nervous system. Synthesis of NGF in tissues innervated by the peripheral nervous system is consistent with its function as a target-derived trophic factor. However, the presence of low- and high-affinity NGF receptors in the gonads suggests another function for the NTs within the reproductive endocrine system. We now report that NGF is required for the growth of primordial ovarian follicles, a process known to occur independently of pituitary gonadotropins. Both the NT receptor p75(NTR) and the NGF tyrosine kinase receptor trkA were found to be expressed in the ovaries of infantile normal mice and mice carrying a null mutation of the NGF gene. The ovaries from homozygote NGF-null (-/-) mutant animals, analyzed after completion of ovarian histogenesis, exhibited a markedly reduced population of primary and secondary follicles in the presence of normal serum gonadotropin levels, and an increased number of oocytes that failed to be incorporated into a follicular structure. Assessment of mitogenic activity using two complementary prolife...Continue Reading

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Citations

Jun 6, 2012·TheScientificWorldJournal·Gustavo Adolfo PalmaFred Sinowatz
Jul 14, 2007·The Journal of Clinical Investigation·Sabine HegerSergio R Ojeda
Nov 14, 2006·Reproductive Biology and Endocrinology : RB&E·Marcela Julio-PieperCarmen Romero
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