PMID: 9439971Jan 24, 1998Paper

Nerve growth factor (NGF) reduces and NGF antibody exacerbates retinal damage induced in rabbit by experimental ocular hypertension

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
A LambiaseL Aloe

Abstract

It has been shown that intravitreal injection of NGF inhibits ganglion cell degeneration after optic nerve transection and ischemic injury. The aim of our study was to investigate the presence of NGF in aqueous humor and its involvement in retinal damage during ocular hypertension. We used an experimental model of ocular hypertension in rabbit. Before treatment and 4, 10 and 15 days after induction of hypertension, we evaluated histological retinal damage and NGF levels in aqueous humor using an immunoenzymatic assay. Polyclonal anti-NGF antibodies were injected intravitreally into one eye of each rabbit (n = 6), and the animals were killed after 4 days of hypertension. Another group of rabbits (n = 12) was injected retro-ocularly with NGF and killed after 10 or 15 days of treatment for histologic evaluation of the retina. Our data show that experimental ocular hypertension in adult rabbits induces retinal damage and enhances local NGF levels. The highest NGF value was found after 4 days of intraocular hypertension: high levels persisted, though to a lesser extent, for up to 15 days. Histological examination revealed that the number of retinal ganglion cells (RGC) remained unchanged during the first 4 days but decreased at 10 d...Continue Reading

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Citations

Aug 30, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Marco CoassinLuigi Aloe
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Alessandro LambiaseRita Levi-Montalcini
Nov 30, 2012·Journal of Translational Medicine·Luigi AloeLuigi Manni
Aug 20, 2008·BMC Research Notes·Kakarla V ChalamRavi K Murthy
Mar 15, 2014·International Journal of Cell Biology·Bijorn Omar BalzaminoAlessandra Micera
Apr 23, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Arianna CalzaPaola Tirassa
Sep 12, 2015·Journal of Medicinal Chemistry·Rebecca K Donegan, Raquel L Lieberman
Feb 7, 2014·Journal of Cellular Physiology·Gloria RobertiMarco Centofanti
Nov 25, 2004·Cytokine & Growth Factor Reviews·Alessandra MiceraStefano Bonini
Jun 20, 2013·Growth Factors·Luigi ManniLuigi Aloe
Jan 5, 2000·Multiple Sclerosis : Clinical and Laboratory Research·A MiceraL Aloe
Mar 30, 2011·Neurorehabilitation and Neural Repair·Benedetto FalsiniRiccardo Riccardi
Feb 24, 2011·Neurorehabilitation and Neural Repair·Antonio ChiarettiRiccardo Riccardi
Feb 17, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Maria Luisa RoccoAlessandra Micera
Jan 30, 2004·Journal of Neurobiology·Marcelo RudzinskiH Uri Saragovi
Oct 12, 2002·The Journal of Biological Chemistry·Anat ShirvanArieh S Solomon
Sep 14, 2013·European Journal of Ophthalmology·Flavio MantelliLuigi Aloe
Dec 26, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Maria Luisa RoccoAlessandra Micera
Mar 2, 2021·Seminars in Ophthalmology·Levi N Kanu, Joseph B Ciolino

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