Nerve growth factor promotes human sperm motility in vitro by increasing the movement distance and the number of A grade spermatozoa

Andrologia
Kai LinY-Q Zhao

Abstract

Nerve growth factor (NGF) was first found in the central nervous system and is now well known for its multiple pivotal roles in the nervous system and immune system. However, more and more evidences showed that NGF and its receptors TrkA and p75 were also found in the head and tail of spermatozoa, which indicate the possible effect of NGF on the sperm motility. Nevertheless, the exact role of NGF in the human sperm motility remains unclear until now. In this study, we investigated the effect of NGF on human sperm motility, and the results showed that NGF could promote human sperm motility in vitro by increasing the movement distance and the number of A grade spermatozoa. Further analysis demonstrated that NGF promoted the sperm motility in a dose-dependent manner in vitro. These results may facilitate the further studies on human fertility and assisted reproduction techniques.

References

Sep 1, 1992·Trends in Neurosciences·S O Meakin, E M Shooter
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C Ayer-LeLievreH Persson
Jul 5, 2001·Cellular and Molecular Life Sciences : CMLS·C Wiesmann, A M de Vos
May 17, 2007·Current Neurovascular Research·Marios G LykissasAlexandros E Beris
Sep 4, 2007·Progress in Brain Research·Devin K Binder
Dec 30, 2008·Gene Expression·Paulette Bernd
Apr 23, 2009·The Journal of International Medical Research·Y ChenK Kong
Jun 4, 2010·The Journal of Reproduction and Development·WanZhu JinKazuyoshi Taya
Jul 16, 2010·Neurological Research·Yan HouGeng-Tao Liu
Apr 5, 2012·Neural Plasticity·Alessandra BerryEnrico Alleva
Sep 21, 2012·Methods in Molecular Biology·David Mortimer, Sharon T Mortimer
Oct 30, 2012·Neurochemistry International·Joseph K EiblGregory M Ross
Nov 30, 2012·Journal of Translational Medicine·Luigi AloeLuigi Manni
Jun 20, 2013·Growth Factors·Luigi ManniLuigi Aloe

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Citations

Aug 29, 2019·Scientific Reports·Molly EstillStephen A Krawetz
Sep 21, 2020·Human Reproduction·Kai XiaChunhua Deng
Sep 24, 2015·Reproduction in Domestic Animals = Zuchthygiene·M MaranesiC Boiti
Nov 14, 2019·Reproductive Biology and Endocrinology : RB&E·Cesare CastelliniMario Rende
May 23, 2020·Theriogenology·Cesare CastelliniAlessandra Pistilli
Mar 21, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Cintia Celina VaquerSilvia Alejandra Belmonte
Feb 1, 2020·Theriogenology·Cesare CastelliniAlessandra Pistilli
Feb 24, 2020·Theriogenology·R M Garcia-GarciaP G Rebollar
Jul 16, 2021·Reproductive Medicine and Biology·Byron AsimakopoulosChrysa Metallinou

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