PMID: 9418961Jan 7, 1998Paper

Nerve growth factor signal transduction in mature pig oligodendrocytes

Journal of Neuroscience Research
H H AlthausR Heumann

Abstract

It has previously been shown that nerve growth factor (NGF) is of functional significance for mature pig oligodendrocytes (OLs) in culture. The present data give evidence for the expression of TrkA, the so-called high-affinity NGF receptor, and of p75NTR, the so-called low-affinity NGF receptor. TrkA is upregulated during culturing, in contrast to the p75 receptor. Exposure of OLs to NGF induces an autophosphorylation of TrkA via its intrinsic tyrosine kinase. K-252a inhibits the TrkA autophosphorylation, which reduces the OL process formation to control levels. To the tyrosine-phosphorylated sites of TrkA several proteins, such as phospholipase C-gamma1, the adaptor protein SHC, the phosphotyrosine phosphatase SH-PTP2 (SYP) associate via their SH2 phosphotase SH-PTP2 domain. The association of SHC to TrkA is shown by co-immunoprecipitation. Indirect evidence for a possible activation of PLC-gamma1 is given by an NGF-induced increase of oligodendroglial [Ca2+]i. Downstream from TrkA, a mitogen-activated protein kinase cascade, which includes Erk1 and Erk2, is operating. An in-gel myelin basic protein kinase assay revealed that NGF activates predominantly Erk1. Finally, it is shown that NGF stimulates expression of c-fos.

References

Jul 1, 1992·Journal of Neuroscience Research·L A HuttonJ R Perez-Polo
Sep 1, 1992·Neuron·J Schlessinger, A Ullrich
Jan 1, 1992·Annual Review of Cell Biology·H Charbonneau, N K Tonks
Sep 4, 1992·Science·S L Pelech, J S Sanghera
Dec 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Dubois-Dalcq, R Armstrong
Jan 1, 1984·Annals of the New York Academy of Sciences·W T Norton
Jun 1, 1984·Die Naturwissenschaften·H H AlthausP Schwartz
Jun 7, 1984·Nature·C W Adams
Sep 7, 1995·Annals of the New York Academy of Sciences·A ObermeierA Ullrich
Sep 7, 1995·Annals of the New York Academy of Sciences·K S RavichandranS J Burakoff
Apr 12, 1994·Biochimica Et Biophysica Acta·L VarticovskiM Susa
Feb 1, 1995·Molecular and Cellular Biology·K S RavichandranS J Burakoff
Oct 1, 1994·Current Opinion in Neurobiology·R Heumann
Feb 1, 1995·Trends in Neurosciences·S J Hopkins, N J Rothwell
Sep 1, 1995·Journal of Neurochemistry·J ZhouW C Mobley
Jul 1, 1995·Trends in Biochemical Sciences·P van der Geer, T Pawson
Sep 22, 1995·The Journal of Biological Chemistry·R A Klinghoffer, A Kazlauskas
Apr 1, 1995·Molecular and Cellular Neurosciences·M V Chao
Jan 1, 1995·Progress in Brain Research·M A Kahn, J de Vellis
Jul 1, 1995·Trends in Neurosciences·M V Chao, B L Hempstead
Jul 1, 1995·Glia·M TakedaB Soliven
Jan 1, 1995·Annual Review of Neuroscience·M Bothwell
Apr 1, 1995·Current Opinion in Cell Biology·M Barbacid
Jun 1, 1995·Journal of Neuroscience Research·L A Hutton, J R Perez-Polo
Jan 1, 1995·Acta Neurologica Scandinavica. Supplementum·J F Kurtzke
Feb 1, 1995·Trends in Biochemical Sciences·Y A Hannun, L M Obeid
Mar 1, 1995·Trends in Biochemical Sciences·E Cano, L C Mahadevan
Dec 1, 1994·Brain : a Journal of Neurology·K OzawaH Lassmann
Oct 1, 1994·Current Opinion in Neurobiology·T N Jelsma, A J Aguayo

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Citations

Apr 28, 2011·Cellular and Molecular Neurobiology·Matthias SchmitzHans H Althaus
Jan 5, 2000·Multiple Sclerosis : Clinical and Laboratory Research·A MiceraL Aloe
Dec 17, 2005·Molecular and Cellular Neurosciences·Yangzhou DuCheryl F Dreyfus
Mar 29, 2001·Microscopy Research and Technique·R L Stariha, S U Kim
Mar 11, 2008·Journal of Molecular Neuroscience : MN·Hans H AlthausMatthias Schmitz
Oct 2, 2009·Journal of Neuroscience Research·Matthias SchmitzHans H Althaus
Sep 22, 2010·Journal of Neuroscience Research·Jason GalvinHolly Colognato
Sep 5, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·V Younes-RapozoP C Barradas
May 30, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R L Stariha, S U Kim
Jun 29, 2012·Journal of Molecular Neuroscience : MN·Matthias SchmitzHans H Althaus
Jul 13, 2012·Journal of Neurochemistry·Junhua XiaoSimon S Murray
Oct 14, 2003·Experimental Neurology·Jianmin ZhangFred J Roisen

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