PMID: 6162531Mar 9, 1981Paper

Nerve growth factor stimulates development of substance P in the embryonic spinal cord

Brain Research
J A Kessler, I B Black

Abstract

Development of the putative neurotransmitter, substance P (SP), in the embryonic rat dorsal root ganglion (DRG) and spinal cord was defined in vivo. SP was not detectable by radioimmunoassay before day 17 of gestation (E17). On E17, cervical sensory ganglia contained 4 pg SP/ganglion, rising to 49 pg/ganglion at birth. The dorsal cervical spinal cord contained 0.75 ng SP/mg protein on E17, rising to 6 ng SP/mg protein on postnatal day 3. The ventral spinal cord contained approximately 20% of the SP content in the dorsal cord at each gestational age. Intrauterine forelimb amputation partially prevented the normal development increase of SP in sensory ganglia destined to innervate that limb, suggesting that target structures regulate the development of peptidergic neruons. Conversely, treatment with nerve growth factor (NGF) stimulated development of SP in the DRG. Moreover, NGF treatment increased SP in the dorsal spinal cord, suggesting that NGF can modulate development within the CNS, as well as peripheral structures. It is likely that the CNS effect reflects NGF peptidergic neruons. Conversely, treatment with nerve growth factor (NGF) stimulated development of SP in the DRG. Moreover, NGF treatment increased SP in the dorsal ...Continue Reading

References

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Citations

Mar 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·H M Liu, K Schmid
Jul 29, 1982·Brain Research·J P SchwartzE M Johnson
Apr 1, 1984·Developmental Biology·J E AdlerI B Black
Jul 1, 1982·Brain Research·S S Mohamed, M E Atkinson
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C S Ayer-LeLievre, A Seiger
Sep 1, 1994·Behavioral and Neural Biology·R U HasenöhrlJ P Huston
Feb 13, 2001·Brain Research Bulletin·P B Farel, D L McIlwain
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J A Kessler, I B Black
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M GoedertU Otten
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M GoedertW Lichtensteiger
Jul 1, 1995·Canadian Journal of Physiology and Pharmacology·J P QuinnC F Morrison
Oct 10, 2002·Annals of Medicine·J Julio Pérez Fontan
Jun 10, 1982·The Journal of Comparative Neurology·E SenbaM Tohyama
Oct 1, 1982·The Journal of Comparative Neurology·V M PickelR J Miller
Jan 1, 1992·Journal of Neuroscience Research·T D JacquinM Denavit-Saubie
Mar 29, 1985·Science·W J FreedR J Wyatt

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