Nerve guidance conduits from aligned nanofibers: improvement of nerve regeneration through longitudinal nanogrooves on a fiber surface

ACS Applied Materials & Interfaces
Chen HuangTong Lin

Abstract

A novel fibrous conduit consisting of well-aligned nanofibers with longitudinal nanogrooves on the fiber surface was prepared by electrospinning and was subjected to an in vivo nerve regeneration study on rats using a sciatic nerve injury model. For comparison, a fibrous conduit having a similar fiber alignment structure without surface groove and an autograft were also conducted in the same test. The electrophysiological, walking track, gastrocnemius muscle, triple-immunofluorescence, and immunohistological analyses indicated that grooved fibers effectively improved sciatic nerve regeneration. This is mainly attributed to the highly ordered secondary structure formed by surface grooves and an increase in the specific surface area. Fibrous conduits made of longitudinally aligned nanofibers with longitudinal nanogrooves on the fiber surface may offer a new nerve guidance conduit for peripheral nerve repair and regeneration.

References

Jul 1, 1986·Journal of the Neurological Sciences·E ToyoshimaR F Mayer
May 14, 1993·Science·R Langer, J P Vacanti
May 1, 1999·Cell Motility and the Cytoskeleton·Z Ahmed, R A Brown
Nov 2, 2001·Nature·A R Parker, C R Lawrence
Oct 7, 2003·Annual Review of Biomedical Engineering·Christine E Schmidt, Jennie Baier Leach
Mar 17, 2004·Biomaterials·Michael E ManwaringPatrick A Tresco
Nov 11, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Steve VucicDidier Cros
Jul 27, 2007·Analytical and Bioanalytical Chemistry·Makiko GotoTakehiko Kitamori
Sep 12, 2008·Nature·Tobias D Wheeler, Abraham D Stroock
Jun 6, 2009·Angewandte Chemie·Christopher J BettingerJeffrey T Borenstein
Aug 1, 2009·Advanced Drug Delivery Reviews·Haoqing CaoSing Yian Chew
Sep 23, 2009·Experimental Neurology·Xu JiangSing Yian Chew
Mar 10, 2010·Developmental Neurobiology·Caitlyn C GertzJoseph M Corey
Jul 1, 2010·Chemical Society Reviews·Kesong LiuLei Jiang
Jul 22, 2010·Nanoscale·Jingwei XieYounan Xia
Sep 21, 2010·Acta Biomaterialia·Chun-Yang WangFeng-Feng Li
Mar 2, 2011·Biomaterials·Ce YanJiandong Ding
Jul 3, 2013·Tissue Engineering. Part B, Reviews·Melissa R Wrobel, Harini G Sundararaghavan
Sep 17, 2013·Advanced Materials·Xiang YaoJiandong Ding
Jun 11, 2014·Biomacromolecules·Rui M A DominguesRui L Reis
May 28, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Soumen Jana, Miqin Zhang
May 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wenjing LuXingyu Jiang
Jan 23, 2007·Soft Matter·Yongmei ZhengLei Jiang

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Citations

Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Xiang WangXiangyu Jin
May 12, 2016·ACS Applied Materials & Interfaces·Mira ChoJae-Hyung Jang
Aug 31, 2016·Scientific Reports·Yu HuMaling Gou
Apr 13, 2017·Scientific Reports·Jie TaoMaling Gou
Apr 4, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Feng RaoPeixun Zhang
Feb 15, 2020·Macromolecular Bioscience·Deteng ZhangChangyou Gao
Feb 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ho Pan BeiXin Zhao
Jul 22, 2018·Neural Regeneration Research·Graham Ka-Hon Shea, Francis Mok
Dec 12, 2019·Frontiers in Bioengineering and Biotechnology·Cristiana R CarvalhoRui L Reis
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Se Rim JangCheol Sang Kim
Nov 13, 2020·Frontiers in Bioengineering and Biotechnology·Benedetta E FornasariStefania Raimondo
May 18, 2021·Bioactive Materials·Wen XueBin Duan
Jul 3, 2021·Burns and Trauma·Yulan HuangMaling Gou
Nov 14, 2016·ACS Biomaterials Science & Engineering·Yaopeng ZhangLujie Song
Nov 28, 2018·ACS Applied Materials & Interfaces·Saranyoo SornkamnerdTatsuo Kaneko

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